Insulin
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Oedema: case report A 32-year-old woman with type 1 diabetes mellitus developed oedema during insulin therapy. The woman, who had a history of non-compliance to insulin therapy, started receiving basal and bolus insulin at increasing daily doses [dosage and route of administration not stated]. She noted significant swelling of her lower extremities, from her feet to her abdomen, 1 week after treatment initiation. After 2 weeks of therapy, she presented with weight gain of 60 pounds, facial swelling and bilateral pitting oedema of her lower extremities. The woman was hospitalised, her sodium and fluid intake was restricted, and furosemide was started; insulin was continued. On hospital day 3, her oedema had significantly improved and she had lost 15 pounds. Her weight was stable at 2-month follow-up, and oedema had not recurred. Author comment: In our patient, "[w]hen insulin was reintroduced, there was sodium and therefore fluid retention directly caused by insulin." Kaur M, et al. Insulin Edema - A Rare Presentation. AAP Capital Letters : abstr. P3-554, 19 Jun 2010. Available from: URL: http://www.endo-society.org 803027238 USA
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Reactions 24 Jul 2010 No. 1311
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