Interactions of betainium and imidazolium-based ionic liquids with peptide amphiphiles and their implications in the for
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ORIGINAL PAPER: SUPRAMOLECULAR MATERIALS
Interactions of betainium and imidazolium-based ionic liquids with peptide amphiphiles and their implications in the formation of nanohybrid composite gels Margaret S. Whalen1 Rachel E. Daso1 Marie F. Thomas2 Ipsita A. Banerjee ●
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Received: 29 June 2020 / Revised: 23 September 2020 / Accepted: 26 October 2020 © Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Ionic liquids (ILs) have been gaining widespread attention due to their plethora of applications. In particular, increasing studies are being carried out to enhance the biological applications of ILs. In this work, a newly synthesized peptide amphiphile comprised of tert-butyl (6-amino-1-((6-aminohexyl) amino)-1-oxohexan-2-yl) carbamate (TAOC) was conjugated with the peptide segment derived from laminin, YIGSR, and self-assembled to form nanofibers. The formed nanofibers were then blended with two separate ionic liquids, betainium bis(trifluoromethylsulfonyl)imide [Hbet][NTf2] and 1-butyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide [C4mim][NTf2] to form nanohybrids. To the nanohybrids, collagen (Type IV) was incorporated to further enhance biocompatibility. Our results indicated that the imidazolium-based nanohybrids formed globular assemblies and displayed higher thermal stability and mechanical strength compared to [Hbet] [NTf2]-based nanocomposites. The binding interactions with the ionic liquids were probed by FTIR spectroscopy, DSC, TGA as well as predictive COSMO-RS studies, which indicated the key role of hydrogen bonding and hydrophobic interactions. Cell studies with neural cortical cells revealed that in both cases, the nanohybrids reduced cytotoxicity compared to the neat ionic liquids. Furthermore, axonal growths were observed. Such ionic liquid infused peptide nanohybrids, particularly the imidazolium-based nanohybrid gels may have potential for biological applications. Graphical Abstract
These authors contributed equally: Margaret S. Whalen, Rachel E. Daso Supplementary information The online version of this article (https:// doi.org/10.1007/s10971-020-05434-5) contains supplementary material, which is available to authorized users. * Ipsita A. Banerjee [email protected] 1
Fordham University, Department of Chemistry, 441 East Fordham Rd., Bronx, NY 10458, USA
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Fordham University, Department of Natural Sciences, 113 West 60th Street, New York, NY 10023, USA
Journal of Sol-Gel Science and Technology
Keywords
Betainium Imidazolium Ionic liquids Nanocomposites Gelatinous matrix ●
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Highlights A new peptide amphiphile (PA) comprised of Boc-Lys conjugated with hexamethylene diamine and YIGSR was synthesized. ● Role of the cationic component of [C4mim][NTf2] and [Hbet][NTf2] on binding interactions with the PA was explored. ● The IL-Pas were integrated with collagen to enhance biocompatibility ● The nanocomposite gels enhanced cell viability compared to neat ILs. ● [C4mim][NTf2]-TAOC-YIGSR-collagen nanogels displayed
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