Intracuff local anesthetic to reduce postoperative sore throat: a randomized clinical trial
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CORRESPONDENCE
Intracuff local anesthetic to reduce postoperative sore throat: a randomized clinical trial Megan McLachlan, MD . Jonathan Gamble, MD, FRCPC . Jennifer M. O’Brien, PhD . William P. McKay, MD, FRCPC . Jagmeet S. Bajwa, MSc
Received: 1 May 2019 / Revised: 2 October 2019 / Accepted: 7 October 2019 Ó Canadian Anesthesiologists’ Society 2019
To the Editor, Postoperative sore throat (POST) following tracheal intubation is reported in 30–70% of patients,1 and is ranked by patients as the sixth most important postoperative complication.2 Instillation of a short-acting local anesthetic, lidocaine, in the endotracheal tube (ETT) cuff reduced postoperative sore throat at one and 24 hr.3 We hypothesized intracuff ropivacaine, a longer acting local anesthetic with a relatively safe cardiovascular toxicity profile, would reduce the severity and incidence of POST on postoperative day one (POD 1). Following Research Ethics Board approval (Bio18-09 2018, March) and protocol registration (NCT03563963), we conducted a randomized blinded multisite clinical trial comparing POST between three groups: 1) ETT cuff inflated with ropivacaine 0.5%, 2) ETT cuff inflated with lidocaine 2%, and 3) ETT cuff inflated with air (standard care). Informed consent was obtained from those participants aged [18 yr, with American Society of Anesthesiologists status I–III, and requiring an ETT and overnight admission for elective gynecological or general surgery. Exclusion criteria were current sore throat, recent upper respiratory tract infection, or intraoperative transesophageal echocardiography. Following endotracheal intubation, the anesthesiologist inflated the ETT cuff with lidocaine 2%, ropivacaine 0.5%, or air using the stethoscope-guided inflation technique
M. McLachlan, MD (&) J. Gamble, MD, FRCPC J. M. O’Brien, PhD W. P. McKay, MD, FRCPC J. S. Bajwa, MSc Department of Anesthesiology, Perioperative Medicine and Pain Management, University of Saskatchewan, Saskatoon, SK, Canada e-mail: [email protected]
described by Kumar and Hirsch4 because our institution’s cuff manometers (VBM Cuff Pressure Gauge— SensitiveTM, Sulz am Neckar, Germany) are not meant to report pressures of a liquid interface. The anesthesiologist documented the volume (mL) instilled into the cuff to create a seal, the ETT cuff pressure after a seal was achieved, any oropharyngeal suctioning, duration of intubation, and incidence and severity of coughing at extubation. The primary outcome was severity of POST assessed on POD 1 using the numerical rating scale (NRS). Patients without POST rated the severity as ‘‘0.’’ Secondary outcomes included: incidence and severity of POST in the postanesthesia care unit (PACU), incidence of POST on POD 1, patient satisfaction, PACU and POD 1 dysphagia, patient-reported hoarseness/dysphonia, and severity of cough at extubation. Sample calculation was based on studies by Ahmady and Estebe reported in the metaanalysis by Lam et al.3 Weighting by sample size, we pooled NRS values on POD 1 from four trials and ca
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