Intradural extramedullary spinal metastasis of renal cell carcinoma: illustrative case report and comprehensive review o
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CASE REPORT
Intradural extramedullary spinal metastasis of renal cell carcinoma: illustrative case report and comprehensive review of the literature Arthur Carminucci1 · Simon Hanft2 Received: 24 March 2020 / Revised: 3 June 2020 / Accepted: 13 July 2020 © Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Study design Literature review. Objectives Intradural metastasis of renal cell carcinoma (RCC) has rarely been reported. We describe a case of an intradural extramedullary spinal metastasis to the cervical spine in a 68-year-old male treated for RCC 22 years prior. Additionally, we review the known reports of both intradural extramedullary and intramedullary of RCC. Methods Case report and literature review. Results A 68-year-old male with a history of right-sided nephrectomy for RCC preformed 22 years prior now presents with a MRI of the cervical spine showing a 1.5 cm contrast enhancing intradural extramedullary lesion at the level of C3–C4. Surgical resection of the lesion was performed. The tumor’s histological and immunohistochemical profile was consistent with metastatic RCC. There are 18 reported cases of intradural extramedullary metastases of sporadic RCC. The average age at diagnosis was 61.6 ± 14.3 years. The interval from diagnosis of primary RCC to diagnosis metastasis ranged from 0 to 264 months (mean 46.8 ± 74.0 months). Sixteen cases of intramedullary renal cell carcinoma metastasis are reported. The average age at time of diagnosis was 53.6 ± 10.2 years. The interval from diagnosis of primary RCC to diagnosis of metastasis ranged from 0 to 180 months (mean 20.9 ± 53.4 months). Conclusion The 22-year interval from diagnosis of primary RCC to intradural metastasis is the longest latency reported in the literature. Intramedullary metastases tend to have a younger age at diagnosis and shorter interval from diagnosis of primary RCC compared to extramedullary lesions. Keywords Renal cell metastasis · Intradural metastasis · Intradural extramedullary spinal metastasis
Introduction Renal cell carcinoma (RCC) is a highly malignant form of cancer. Approximately 30% of patients diagnosed with RCC will present in advanced stages with diffuse metastases [1, 2]. Additionally, 20–40% of patients treated for a primary RCC will go on to develop metastatic disease [1, 2]. The most common sites for metastasis include lung, bone, lymph * Simon Hanft [email protected] 1
Department of Neurological Surgery, Rutgers New Jersey Medical School, Rutgers University, New Brunswick, NJ, USA
Division of Neurosurgery, Department of Neurological Surgery, Rutgers Robert Wood Johnson Medical School, Rutgers University, 10 Plum St, 5th floor, New Brunswick, NJ, USA
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nodes, and liver [3]. Brain metastases account for approximately 8% reported locations [4]. Intradural metastasis of renal cell carcinoma has rarely been reported. We describe a case of an intradural extramedullary spinal metastasis to the cervical spine in a 68-year-old male treated for RCC 22 years prior. Additionally, we r
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