Intrinsic non-hub connectivity predicts human inter-temporal decision-making
- PDF / 2,901,716 Bytes
- 12 Pages / 595.276 x 790.866 pts Page_size
- 95 Downloads / 167 Views
ORIGINAL RESEARCH
Intrinsic non-hub connectivity predicts human inter-temporal decision-making Qiang Wang 1,2,3
&
Yuxuan Zhu 2 & Yajie Wang 2 & Chuansheng Chen 4 & Qinghua He 5,6 & Gui Xue 7
Accepted: 2 September 2020 # Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Inter-temporal decision-making is ubiquitous in daily life and has been considered as a critical characteristic associated with an individual’s success. Such decisions require us to tradeoff between short-term and long-term benefits. Prior studies have indicated that inter-temporal decision involves various brain regions that tend to occupy the central hubs. However, it is unclear whether the functional connectivities among hub as well as non-hub regions can predict discounting behaviors. Here, we combined with graph-theoretical algorithm and multivariate pattern analysis to explore whether voxel-wise functional connectivity strength in the whole brain could predict discounting rates (indexed as logk, based on the adaptive delay-discounting task) in a relatively large sample (n = 429) of young adults. Results revealed that short- and long-distance as well as all-range non-hub functional connectivity strength in the limbic system (i.e., medial orbitofrontal cortex and parahippocampus) were inversely associated with discounting rates. Furthermore, these results were robust and did not appear to be due to potential confounding factors. Above weight-based degree metric is commonly indicative of the communication pattern of local and global parallel information processing, and it therefore provides novel insights into the neural mechanisms underlying inter-temporal decision-making from the perspective of human brain topological organizations. Keywords Inter-temporal decision-making . Multivariate pattern analysis . Functional connectivity strength . Hub region
Introduction Inter-temporal decision-making has been considered as a critical characteristic associated with an individual’s success. In such choices, people are more likely to prefer immediate outcomes rather than future outcomes, which is also called delay-
discounting phenomenon (Bickel et al. 1999; McClure et al. 2004). Steep delay discounting behavior was often observed in substantial psychiatric disorders such as substance abuse (Bickel et al. 1999; Hu et al. 2015), pathological gambling (Alessi and Petry 2003), and attention deficit hyperactivity disorder (ADHD) (Paloyelis et al. 2010).
Electronic supplementary material The online version of this article (https://doi.org/10.1007/s11682-020-00395-3) contains supplementary material, which is available to authorized users. * Qinghua He [email protected] * Gui Xue [email protected] 1
2
3
Key Research Base of Humanities and Social Sciences of the Ministry of Education, Academy of Psychology and Behavior, Tianjin Normal University, Tianjin 300387, China Faculty of Psychology, Tianjin Normal University, Tianjin 300387, China Tianjin Social Science Laboratory of Students’ Mental Development and Learning, Tianjin
Data Loading...
