Investigating the 1-year decline in midbrain-to-pons ratio in the differential diagnosis of PSP and IPD
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ORIGINAL COMMUNICATION
Investigating the 1‑year decline in midbrain‑to‑pons ratio in the differential diagnosis of PSP and IPD Silja Kannenberg1 · Julian Caspers2 · Lars Dinkelbach1 · Alexia‑S. Moldovan1,3 · Stefano Ferrea1 · Martin Südmeyer1,4 · Markus Butz1 · Alfons Schnitzler1 · Christian J. Hartmann1,3 Received: 18 June 2020 / Revised: 10 November 2020 / Accepted: 19 November 2020 © The Author(s) 2020
Abstract Background A reliable measure of PSP-specific midbrain atrophy, the midbrain-to-pons ratio (MTPR) has been reported to support the differential diagnosis of progressive supranuclear palsy (PSP) from idiopathic Parkinson’s disease (IPD). Since longitudinal analyses are lacking so far, the present study aimed to evaluate the diagnostic value of the relative change of MTPR (relΔt_MTPR) over a 1-year period in patients with PSP, IPD, and healthy controls (HC). Methods Midsagittal individual MRIs of patients with PSP (n = 15), IPD (n = 15), and healthy controls (HC; n = 15) were assessed and the MTPR at baseline and after 1 year were defined. The diagnostic accuracy of the MTPR and its relative change were evaluated using ROC curve analyses. Results PSP-patients had a significantly lower MTPR at baseline (M = 0.45 ± 0.06), compared to both non-PSP groups (F (2, 41) = 62.82, p
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