Investigation of reactive astrogliosis effect on post-stroke cognitive impairment
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(2020) 17:308
RESEARCH
Open Access
Investigation of reactive astrogliosis effect on post-stroke cognitive impairment Kuo-Lun Huang1† , Ing-Tsung Hsiao2,3†, Meng-Yang Ho1,4, Jung-Lung Hsu5,6, Yeu-Jhy Chang1, Ting-Yu Chang1, Chi-Hung Liu1, Chien-Hung Chang1, Yi-Ming Wu7, Kuan-Yi Wu8, Shiaw-Pyng Wey2,3, Tzu-Chen Yen2,3, Nobuyuki Okamura9,10, Tsong-Hai Lee1* and Kun-Ju Lin2,3*
Abstract Background: The aim of this study is to investigate the associations between post-stroke cognitive impairment (PSCI) severity and reactive astrogliosis (RA) extent on normalized 18F-THK-5351 positron-emission tomography (PET) imaging in amyloid-negative patients with first-ever stroke. Methods: We prospectively enrolled 63 amyloid-negative patients with first-ever stroke. Neurocognitive evaluation, MRI, 18F-THK-5351, and 18F-florbetapir PET were performed around 3 months after stroke. The 18F-THK-5351 uptake intensity was normalized using a signal distribution template to obtain the Z-SUM scores as the RA extent in the whole brain and cerebral hemisphere ipsilateral to stroke lesion. We evaluated stroke volume, leukoaraiosis, and brain atrophy on MRI. We used a comprehensive neurocognitive battery to obtain composite cognitive scores, and defined PSCI as a general cognitive function score < − 1. We analyzed the influence of Z-SUM scores on PSCI severity after adjusting for demographic, vascular, and neurodegenerative variables. Results: Twenty-five of 63 stroke patients had PSCI. Patients with PSCI had older age, lower education, and more severe cortical atrophy and total Z-SUM scores. Total Z-SUM scores were significantly associated with general cognitive and executive functions at multiple regression models. Path analyses showed that stroke can exert cognitive influence directly by stroke itself as well as indirectly through RA, including total and ipsilateral Z-SUM scores, in patients with either right or left hemisphere stroke. Conclusion: The patterns and intensity of 18F-THK-5351 uptake in amyloid-negative patients with first-ever stroke were associated with PSCI manifestations, which suggests that RA presents a modulating effect in PSCI development. Keywords: Post-stroke cognitive impairment, Reactive astrogliosis, PET, Stroke
* Correspondence: [email protected]; [email protected] † Kuo-Lun Huang and Ing-Tsung Hsiao contributed equally to this work. 1 Department of Neurology, Linkou Chang Gung Memorial Hospital, and College of Medicine, Chang Gung University, No. 5, Fuxing St., Guishan, Taoyuan, Taiwan 2 Department of Nuclear Medicine and Molecular Imaging Center, Linkou Chang Gung Memorial Hospital, No. 5, Fuxing St., Guishan, Taoyuan, Taiwan Full list of author information is available at the end of the article © The Author(s). 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link
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