Iodine-131

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Benign thyroid nodules: 9 case reports A retrospective study of 117 paediatric patients with Grave’s disease, who had received a radioiodine therapy (RIT) at a clinic in Japan between July 1999 and December 2018, described 9 patients [including six women in 20s, one adult woman, one male patient and one female patient; not all ages stated], who developed benign thyroid nodules following treatment with iodine-131 for juvenile Grave’s disease [routes, dosages, durations of treatments to reactions onsets and outcomes not stated]. Nine patients had juvenile Grave’s disease. Therefore, the patients received unspecified antithyroids. However antithyroids were stopped due to unspecified reasons, and the patients and their parents refused surgical therapy. Therefore, at the ages of 15–18 years, the patients started receiving RIT with iodine-131 at the dose of 4–13mCi, on outpatient basis. Eight of these patients received only one dose of iodine-131, and the remaining one patient received second dose of iodine-131 at the age of 22 years. The absorbed doses to the thyroid were 86–285Gy. All patients underwent ultrasonography of the thyroid gland before and after RIT. The thyroid volumes prior to administration of iodine-131 were 16–50mL. Ultrasound examination performed after 52–200 months from the first administration of iodine-131 showed iso- or hypo-echoic solid nodule(s) in the thyroid of all nine patients. The nodules were small (3.2–13.2mm) and appeared benign. At that time thyroid volumes were 0.9–12.2mL (decreased in all the patients), and two patients had normal thyroid function. In all nine patients previous ultrasound examinations did not detect any new nodules (seven patients were adults at that time). The most recent ultrasound examination performed at 84–215 months from the first administration of iodine-131 showed that the nodules had enlarged in four patients and the number of the nodules had also increased in four patients. The sizes of the nodules were 4.4–13.6mm and thyroid volumes were 1.8–9.8mL. Fine-needle aspiration biopsy was performed in four patients with benign cytologic diagnoses. Seven of these patients had achieved hypothyroidism and were receiving levothyroxine sodium maintenance, while remaining two patients had euthyroidism (normal thyroid function). Mizokami T, et al. Long-Term Outcomes of Radioiodine Therapy for Juvenile Graves Disease with Emphasis on Subsequently Detected Thyroid Nodules: A Single Institution 803508087 Experience from Japan. Endocrine Practice 26: 729-737, No. 7, Jul 2020. Available from: URL: http://doi.org/10.4158/EP-2019-0468

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Reactions 17 Oct 2020 No. 1826

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