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Iatrogenic hypothyroidism: case report A woman developed iatrogenic hypothyroidism in her late 50s following treatment with radioactive iodine for inappropriately diagnosed thyrotoxicosis. The woman was diagnosed with thyrotoxicosis in 2003, at the age of 49 years. She received unspecified antithyroid drug for 18 months and her disease was in remission. She again presented at the age of 55 years in December 2009 with weight loss and anxiety. Findings revealed elevated thyroxine. She started receiving carbimazole. In April 2011 during carbimazole treatment laboratory findings showed discordant test results with a normal thyroid stimulating hormone (TSH) and an elevated free thyroxine (fT4). Therefore, in May 2011 she underwent radioactive iodine thyroid ablation, and her fT4 was normalised. Thus, her the carbimazole treatment was discontinued. In May 2013 thyroid function test revealed elevated TSH and decreased fT4, which was consistent with post-radioactive iodine hypothyroidism. The woman, received thyroxine replacement and her TSH was normalised by June 2014. However, in June 2016 both TSH and fT4 were found to be elevated despite good compliance with the treatment. On further testing she was diagnosed with familial dysalbuminaemic hyperthyroxinaemia, which was inappropriately diagnosed as thyrotoxicosis. Lau NKC, et al. Familial dysalbuminaemic hyperthyroxinaemia with discordant thyroid function test results: Two case reports. Hong Kong Medical Journal 26: 243-247, No. 803500079 3, Jun 2020. Available from: URL: http://doi.org/10.12809/hkmj198035

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Reactions 5 Sep 2020 No. 1820