Iris surface features and anterior chamber depth in Chinese adolescents
- PDF / 1,765,462 Bytes
- 6 Pages / 595.276 x 790.866 pts Page_size
- 72 Downloads / 228 Views
RESEARCH ARTICLE
Open Access
Iris surface features and anterior chamber depth in Chinese adolescents Chen-Wei Pan1, Yu-Xi Qian1, Jun Li2 and Hua Zhong3*
Abstract Background: We aim to determine the association of iris surface features including crypts, color and contraction furrows with anterior chamber depth (ACD) in a school-based sample of Chinese teenagers. Methods: Totally, 2346 students aged 13 to 14 years in Mojiang located in the Southwestern part of China contributed to this analysis. Iris surface features were graded based on standardized slit-lamp photographs. Ocular biometric parameters including ACD were measured using an IOL Master. Generalized estimating equation was incorporated in the linear regression models to assess the relationship between iris surface features and ACD. Results: A significant trend of increasing ACDs with more contraction furrows were observed. On average, the mean ACD was 3.03 mm in participants with contraction furrows of grade 1 while it was 3.10 mm in those with grade 3 (mean difference, 0.07 mm, P = 0.01). Adjusting for other potential confounders such as gender, height and weight did not significantly changed the associations. Compared with individuals with contraction furrows of grade 1, those with grade 3 had a greater ACD of 0.06 mm (95% confidence interval: 0.01, 0.11) in multivariate-adjusted model. There were no significant relationships between ACD and iris crypts or color. (P > 0.10). Conclusions: More iris contraction furrows are associated with greater ACDs while the association with iris color and crypts were not significant. Keywords: Iris surface, Contraction furrows, Anterior chamber depth, Epidemiology
Background Primary angle closure glaucoma (PACG), a major cause of irreversible visual impairment and blindness, is a worldwide health concern and is particularly prevalent in Chinese and individuals of East Asian ancestry [1]. Anterior chamber depth (ACD) of the eye is an important ocular parameter, especially in the diagnosis and prediction of primary angle closure glaucoma (PACG) [2]. Numerous studies have shown that individuals with PACG are characterized with narrower anterior chamber angle [3–5]. Thus, from the perspectives of disease prevention, the determinants of ACD need to be further elucidated, especially in younger generations. * Correspondence: [email protected] 3 Department of Ophthalmology, the First Affiliated Hospital of Kunming Medical University, 295 Xichang Road, Kunming 650032, China Full list of author information is available at the end of the article
Crypts, color and contraction furrows are the three major features that could be easily observed in the surface of iris. Previous studies have observed associations of some geometric parameters of iris such as thickness, cross-sectional area, and convexity with angle closure diseases, which emphasize the role of the iris in the pathogenesis of PACG [6, 7]. However, these geometric parameters are not easy to obtain and require technical expertise and sophisticated instruments such as
Data Loading...
