Isoquinolines And Beta-Carbolines As Neurotoxins And Neuroprotectants
This book summarizes, for the first time, the results from behavioral, neurochemical and molecular experiments, which demonstrate a wide spectrum of tetrahydroisoquinolines (TIQs) and beta-carbolines (BCs) effects - from their rather mild neurot
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Lucyna Antkiewicz-Michaluk Hans Rommelspacher Editors
Isoquinolines and Beta-Carbolines as Neurotoxins and Neuroprotectants New Vistas In Parkinson’s Disease Therapy
Editors Lucyna Antkiewicz-Michaluk Department of Neurochemistry Institute of Pharmacology Polish Academy of Sciences 1231-343 Kraków, Poland [email protected]
Hans Rommelspacher Department of Psychiatry Charité-University Medicine Campus Benjamin Franklin Charitéplatz 1 10117 Berlin, Germany [email protected]
ISBN 978-1-4614-1541-1 e-ISBN 978-1-4614-1542-8 DOI 10.1007/978-1-4614-1542-8 Springer New York Dordrecht Heidelberg London Library of Congress Control Number: 2011942264 © Springer Science+Business Media, LLC 2012 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Preface
The specific topic “Isoquinolines and Beta-Carbolines as Neurotoxins and Neuroprotectants: New Perspectives in Parkinson’s Disease Therapy,” was chosen in light of accumulating neurobiological evidence indicating that, in addition to exogenous neurotoxins (e.g., 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine [MPTP]), endogenous compounds may play an important role in the most common neurodegenerative disorders (e.g., Parkinson’s disease). Two groups of amine-related compounds, which appeared chemically like MPTP, were detected in human brain and cerebrospinal fluid (CSF): b-carbolines (BCs) and tetrahydroisoquinolines (TIQs). These are heterocyclic compounds formed endogenously from phenylalanine/ tyrosine (TIQs) and tryptophan, tryptamine, and 5-hydroxytryptamine (BCs), respectively, and exert a wide spectrum of psychopharmacological and behavioral effects. The TIQs and BCs may bind to their own high-affinity sites on neuronal membranes associated with or located close to the receptors of neurotransmitters. Research on TIQs and BCs is stimulated also by their possible role in pathological conditions, especially parkinsonism and alcoholism. Recently, clinical interest has been spurred by their role as neuroprotective, and even neurorestorative, anticonvulsant, and antiaddictive, substances. In this book we are going to summarize, for the first time, the results from behavioral, neurochemical, and molecular experiments, which demonstrat
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