Issues in Clinical Epileptology: A View from the Bench

This book is dedicated to Dr. Philip A. Schwartzkroin.  The book has a novel format because it is not intended to be a set of reviews. Instead, it is an effort to explore important topics in the epilepsy research field. Because articles are written b

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Helen E. Scharfman Paul S. Buckmaster Editors

Issues in Clinical Epileptology: A View from the Bench

Advances in Experimental Medicine and Biology Volume 813

Advances in Experimental Medicine and Biology Series Editor: JOHN D. LAMBRIS, University of Pennsylvania, Philadelphia, PA, USA

Editorial Board: IRUN R. COHEN, The Weizmann Institute of Science, Rehovot, Israel ABEL LAJTHA, N.S. Kline Institute for Psychiatric Research, Orangeburg, NY, USA RODOLFO PAOLETTI, University of Milan, Milan, Italy

For further volumes: http://www.springer.com/series/5584

Helen E. Scharfman • Paul S. Buckmaster Editors

Issues in Clinical Epileptology: A View from the Bench Helen E. Scharfman The Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY, USA Departments of Child & Adolescent Psychiatry, Physiology & Neuroscience, and Psychiatry, New York University Langone Medical Center, New York, NY, USA Paul S. Buckmaster Departments of Comparative Medicine and Neurology & Neurological Sciences, Stanford University, Stanford, CA, USA

Editors Helen E. Scharfman The Nathan S. Kline Institute for Psychiatric Research Orangeburg, NY, USA Departments of Child & Adolescent Psychiatry, Physiology & Neuroscience, and Psychiatry New York University Langone Medical Center New York, NY, USA

Paul S. Buckmaster Departments of Comparative Medicine and Neurology & Neurological Sciences Stanford University Stanford, CA, USA

ISSN 0065-2598 ISSN 2214-8019 (electronic) ISBN 978-94-017-8913-4 ISBN 978-94-017-8914-1 (eBook) DOI 10.1007/978-94-017-8914-1 Springer Dordrecht Heidelberg New York London Library of Congress Control Number: 2014942054 © Springer Science+Business Media Dordrecht 2014 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection with reviews or scholarly analysis or material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Duplication of this publication or parts thereof is permitted only under the provisions of the Copyright Law of the Publisher’s location, in its current version, and permission for use must always be obtained from Springer. Permissions for use may be obtained through RightsLink at the Copyright Clearance Center. Violations are liable to prosecution under the respective Copyright Law. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore