Itraconazole
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Cardiovascular disorders: 4 case reports Four men developed cardiovascular disorders 3 weeks to 4 months after starting treatment with itraconazole 400 mg/day for chronic necrotising pulmonary aspergillosis. Three weeks after starting itraconazole, a 58-year-old man, who had a history of diabetes mellitus, hypertension and ’old’ tuberculosis, developed congestive heart failure. He received diuretics and improved. Itraconazole was withdrawn [patient outcome not clearly stated]. A 71-year-old man, who had a history of ’old’ tuberculosis, diabetes mellitus with nephropathy, and hypertension, was receiving itraconazole. He presented again 10 weeks later with congestive heart failure and acute on chronic renal failure [duration of treatment before reaction onset not clearly stated]. Itraconazole was discontinued. He received diuretic treatment and had an improvement; his serum creatinine level returned to baseline levels [patient outcome not clearly stated]. A 55-year-old man with a baseline BP of 110/70mm Hg started receiving itraconazole. After 3 months, his BP increased to 160/90mm Hg. He started receiving antihypertensive therapy and itraconazole was continued. [Patient outcome not stated.] A 60-year-old man with silicosis and ’old’ tuberculosis started receiving itraconazole. Subsequently, his baseline BP increased from 100/70 to120/80mm Hg [duration of treatment before reaction onset not clearly stated]. He was put under observation. Itraconazole was continued. Fifteen weeks after itraconazole was started, he died (2 days after his last medical follow-up). The cause of the death was uncertain but was suspected to be a major cardiac arrhythmia. Fung S-L, et al. Cardiovascular adverse effects during itraconazole therapy. 801117023 European Respiratory Journal 32: 240, No. 1, Jul 2008 - China
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Reactions 12 Jul 2008 No. 1210
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