Joint Diabetic Macular Edema Segmentation and Characterization in OCT Images
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ORIGINAL PAPER
Joint Diabetic Macular Edema Segmentation and Characterization in OCT Images Joaquim de Moura1,2 Marcos Ortega1,2
4,5,6 · ´ · Gabriela Samagaio3 · Jorge Novo1,2 · Pablo Almuina4 · Mar´ıa Isabel Fernandez
© Society for Imaging Informatics in Medicine 2020
Abstract The automatic identification and segmentation of edemas associated with diabetic macular edema (DME) constitutes a crucial ophthalmological issue as they provide useful information for the evaluation of the disease severity. According to clinical knowledge, the DME disorder can be categorized into three main pathological types: serous retinal detachment (SRD), cystoid macular edema (CME), and diffuse retinal thickening (DRT). The implementation of computational systems for their automatic extraction and characterization may help the clinicians in their daily clinical practice, adjusting the diagnosis and therapies and consequently the life quality of the patients. In this context, this paper proposes a fully automatic system for the identification, segmentation and characterization of the three ME types using optical coherence tomography (OCT) images. In the case of SRD and CME edemas, different approaches were implemented adapting graph cuts and active contours for their identification and precise delimitation. In the case of the DRT edemas, given their fuzzy regional appearance that requires a complex extraction process, an exhaustive analysis using a learning strategy was designed, exploiting intensity, texture, and clinical-based information. The different steps of this methodology were validated with a heterogeneous set of 262 OCT images, using the manual labeling provided by an expert clinician. In general terms, the system provided satisfactory results, reaching Dice coefficient scores of 0.8768, 0.7475, and 0.8913 for the segmentation of SRD, CME, and DRT edemas, respectively. Keywords Computer-aided diagnosis · Retinal imaging · Optical coherence tomography · Diabetic macular edema · Fluid segmentation
Introduction The presence of macular edemas (ME) constitutes a retinal disease that produces, as main symptoms, a blurred or wavy central vision that could also induce a change in the color perception of the visual acuity [24]. Different medical studies reported that this eye disorder is caused by damage in the retinal microvascularity that consequently carries a problematic leak of blood within the retinal tissues. The presence of this intraretinal fluid leads to a significant deterioration of the morphology and architecture of the retinal tissues (especially regarding its thickness), reducing consequently the visual acuity of the patient.
Joaquim de Moura
[email protected]
Extended author information available on the last page of the article.
This eye fundus pathology is prevalent in advanced stages of significant retinal diseases including diabetic macular edema (DME) or age-related macular degeneration (AMD). DME is considered one of the leading causes of blindness and visual impairment among working-aged adults in
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