Ketamine
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Cardiac arrest and hypotension in paediatric patients: 3 case reports From a study, two paediatric patients, aged 5 months and 12 years, respectively, were identified after they developed hypotension while receiving ketamine, and a 17-month old infant was identified after they developed cardiac arrest while receiving ketamine. All of the patients [sexes not stated] underwent surgical treatment for pericardial effusion and received ketamine for induction of anaesthesia [dosages and routes not stated]. Two of the patients developed hypotension post-induction, while the remaining patient developed bradycardia following by pulseless electrical activity post-induction [durations of treatments to reaction onsets not stated]. Two patients received dobutamine and epinephrine [adrenaline], respectively, for hypotension. One of these patients improved with pericardiocentesis [outcome of other patient not stated]. The remaining patient received epinephrine and CPR, and underwent insertion of a pericardial drain for cardiac arrest. Five minutes later, spontaneous circulation was restored without neurological sequelae. All three patients were extubated and admitted to an ICU. Author comment: "We experienced one cardiac arrest and two cases of hypotension requiring treatment with inotropes following induction with ketamine, suggesting the drug is not a panacea in all cases." Rawlinson E, et al. Anesthesia for children with pericardial effusion: A case series. Pediatric Anesthesia 22: 1124-1131, No. 11, Nov 2012. Available from: URL: 803084352 http://dx.doi.org/10.1111/j.1460-9592.2012.03894.x - United Kingdom
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Reactions 16 Mar 2013 No. 1443
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