Kidney Involvement in GVHD
There are numerous causes of acute and chronic kidney disease following HSCT. Excluding nephrotoxic drugs and infections, the role of GVHD in the genesis of several glomerulopathies is a controversial or incompletely understood subject. Transplant-associa
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Pathology of Graft vs. Host Disease
Cecilia C. S. Yeung • Howard M. Shulman Editors
Pathology of Graft vs. Host Disease A Case Based Teaching Guide
Editors Cecilia C. S. Yeung Clinical Research Division Fred Hutchinson Cancer Research Center Seattle, WA USA
Howard M. Shulman Clinical Research Division Fred Hutchinson Cancer Research Center Seattle, WA USA
Department of Pathology University of Washington School of Medicine Seattle, WA USA
Department of Pathology University of Washington School of Medicine Seattle, WA USA
Pathology Section Seattle Cancer Care Alliance Seattle, WA USA
Pathology Section Seattle Cancer Care Alliance Seattle, WA USA
ISBN 978-3-319-42098-1 ISBN 978-3-319-42099-8 (eBook) https://doi.org/10.1007/978-3-319-42099-8 Library of Congress Control Number: 2018963219 © Springer Nature Switzerland AG 2019 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Switzerland AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
Foreword: Why Have a Histopathology Primer on Graft-vs-Host Disease (GVHD)?
In 45 years, HSCT has emerged from a last-ditch experimental effort to cure hematologic malignancies into an established treatment with hundreds of transplant centers throughout the world. Despite the numerous technological advances leading to successful outcomes, GVHD with its associated immunodeficiency and infectious vulnerability remains the leading cause of non-relapse mortality. The advances in the HSCT procedure, along with changes in management of GVHD, have produced an additional set of considerations related to the interpretation of biopsies for diagnosing GVHD and evaluating response to anti-GVHD treatment. These considerations include distinguishing GVHD from pre-transplant conditioning chemo-irradiation toxicities, fr
