Kisspeptin Signaling in Reproductive Biology
Kisspeptin has been shown to be both necessary and sufficient for activation of the reproductive axis, during puberty and later in adulthood. This makes kisspeptin a fundamental component of the reproductive axis. Kisspeptin has been deemed the sing
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Alexander S. Kauffman • Jeremy T. Smith Editors
Kisspeptin Signaling in Reproductive Biology
Editors Alexander S. Kauffman Department of Reproductive Medicine University of California, San Diego La Jolla, CA, USA
Jeremy T. Smith School of Anatomy, Physiology and Human Biology The University of Western Australia Nedlands, WA, Australia
ISSN 0065-2598 ISBN 978-1-4614-6198-2 ISBN 978-1-4614-6199-9 (eBook) DOI 10.1007/978-1-4614-6199-9 Springer New York Heidelberg Dordrecht London Library of Congress Control Number: 2013932777 © Springer Science+Business Media, LLC 2013 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection with reviews or scholarly analysis or material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Duplication of this publication or parts thereof is permitted only under the provisions of the Copyright Law of the Publisher’s location, in its current version, and permission for use must always be obtained from Springer. Permissions for use may be obtained through RightsLink at the Copyright Clearance Center. Violations are liable to prosecution under the respective Copyright Law. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. While the advice and information in this book are believed to be true and accurate at the date of publication, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Preface
We were lucky to get into the kisspeptin “field” during its early days, though we had different avenues of entry. In early 2004, Sasha was a postdoctoral fellow in Dr. Emilie Rissman’s lab in Virginia, where he was studying the effects of various reproductive neuropeptides, such as GALP and GnRH variants, on sex behavior. Dr. Rissman asked whether Sasha would be interested in studying sexual behavior and sexual differentiation in a newly created transgenic mouse that was lacking an orphan receptor called GPR54. This was just months after several high-profile (and soon-to-be seminal) p
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