Lack of association of two common polymorphisms on 9p21 with risk of coronary heart disease and myocardial infarction; r
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BioMed Central
Open Access
Research article
Lack of association of two common polymorphisms on 9p21 with risk of coronary heart disease and myocardial infarction; results from a prospective cohort study Abbas Dehghan1, Mandy van Hoek2, Eric JG Sijbrands2, Ben A Oostra3, Albert Hofman1, Cornelia M van Duijn1 and Jacqueline CM Witteman*1 Address: 1Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands, 2Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands and 3Department of Clinical Genetics, Erasmus Medical Center, Rotterdam, the Netherlands Email: Abbas Dehghan - [email protected]; Mandy van Hoek - [email protected]; Eric JG Sijbrands - [email protected]; Ben A Oostra - [email protected]; Albert Hofman - [email protected]; Cornelia M van Duijn - [email protected]; Jacqueline CM Witteman* - [email protected] * Corresponding author
Published: 16 October 2008 BMC Medicine 2008, 6:30
doi:10.1186/1741-7015-6-30
Received: 31 January 2008 Accepted: 16 October 2008
This article is available from: http://www.biomedcentral.com/1741-7015/6/30 © 2008 Dehghan et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract Background: Recent genome wide association (GWA) studies identified two Single Nucleotide Polymorphisms (SNP) (rs10757278 and rs10757274) in the region of the CDK2NA and CDK2NB genes to be consistently associated with the risks of coronary heart disease (CHD) and myocardial infarction (MI). We examined the SNPs in relation to the risk of CHD and MI in a large population based study of elderly population. Methods: The Rotterdam Study is a population-based, prospective cohort study among 7983 participants aged 55 years and older. Associations of the polymorphisms with CHD and MI were assessed by use of Cox proportional hazards analyses. Results: In an additive model, the age and sex adjusted hazard ratios (HRs) (95% confidence interval) for CHD and MI were 1.03 (0.90, 1.18) and 0.94 (0.82, 1.08) per copy of the G allele of rs10757274. The corresponding HRs were 1.03 (0.90, 1.18) and 0.93 (0.81, 1.06) for the G allele of rs10757278. The association of the SNPs with CHD and MI was not significant in any of the subgroups of CHD risk factors. Conclusion: we were not able to show an association of the studied SNPs with risks of CHD and MI. This may be due to differences in genes involved in the occurrence of CHD in young and older people.
Background It has been considered for long that genes play a substantial role in susceptibility to coronary heart disease (CHD) [1]. Up to now, a limited number of these genes have been identified through the candidate gene approach and genome wide linkage studies. Recently a number of
genome wide association (GWA) studies have ident
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