Lack of relationship between right ventricular volume, degree of pulmonic regugitation (PR) and left ventricular functio
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Lack of relationship between right ventricular volume, degree of pulmonic regugitation (PR) and left ventricular function in repaired Tetralogy of Fallot (TOF) Tsun-Hou Chang1 and Harold Litt*2 Address: 1Tri-Service General Hospital, Taipei, Taiwan and 2University of Pennsylvania School of Medicine, Philadelphia, PA, USA * Corresponding author
from 13th Annual SCMR Scientific Sessions Phoenix, AZ, USA. 21-24 January 2010 Published: 21 January 2010 Journal of Cardiovascular Magnetic Resonance 2010, 12(Suppl 1):O30
doi:10.1186/1532-429X-12-S1-O30
Abstracts of the 13th Annual SCMR Scientific Sessions - 2010
Meeting abstracts - A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/files/pdf/1532-429X-11-S1-infoThis abstract is available from: http://jcmr-online.com/content/12/S1/O30 © 2010 Chang and Litt; licensee BioMed Central Ltd.
Introduction Previous studies of small numbers of patients have shown conflicting results concerning the effect of RV dilation and PR on LV function, with some showing an inverse correlation between LV EF and RV volume and pulmonic regurgitant fraction, and others demonstrating no effect.
Purpose To evaluate the correlation between LV EF and RV volume and degree of PR in a larger group of patients with repaired TOF.
between RV EDV and degree of PR, r2 = 0.2 (0.29 if outlying RV sizes are excluded) (Figure 3)
Conclusion No significant relationship was detected between LV ejection fraction and RV size or degree or PR in a large, heterogeneous group of adults with repaired TOF. LV function remains well preserved in many patients with very large RV volume and severe PR. Diminished LV function can occur with any level of RV dilation or pulmonic regurgitation, and appears to be related to factors other than RV volume overload.
Methods 103 consecutive MRI exams performed on adults with repaired TOF from 2005-2009 were reviewed; 11 studies obtained after pulmonic valve replacement were excluded, leaving 92 exams in 78 patients for analysis. RV end-diastolic volume (indexed to body surface area) and LV EF, obtained from SSFP cine images, and pulmonic regurgitant fraction, obtained from velocity encoded phase contrast images, were recorded.
Results Mean indexed RV EDV was 149 ml/m^2 (range 67-404), mean pulmonic regurgitant fraction was 27% (range 066) and mean LV EF was 56% (range 32-73). There was no significant correlation between either RV EDV or PR and LV ejection fraction, (r2 = 0.005 and 0.03, respectively) (Figures 1 and 2). There was a moderate correlation
Figure LV EF vs.1 RV EDV LV EF vs. RV EDV.
Page 1 of 2 (page number not for citation purposes)
Journal of Cardiovascular Magnetic Resonance 2010, 12(Suppl 1):O30
http://jcmr-online.com/content/12/S1/O30
Figure LV EF vs.2 PR% LV EF vs. PR%.
Figure PR% vs. 3RV EDV$$ PR% vs. RV EDV$$.
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