• PDF / 170,145 Bytes
• 1 Pages / 595.245 x 841.846 pts (A4) Page_size
• 7 Downloads / 130 Views

DOWNLOAD

REPORT

---

1 S

Lamotrigine/letrozole Mania and stevens-johnson syndrome: case report

An adult woman [age at reaction onset not stated] developed Stevens-Johnson syndrome during treatment with lamotrigine for bipolar disorder, and mania during therapy with letrozole for aiding in ovulation and pregnancy [routes, dosages and outcomes not stated; not all durations of treatment to reactions onsets stated]. The woman was a married registered nurse, who was diagnosed with ultra-rapid cycling bipolar disorder. She presented with an unusual picture of manic/hypomanic episodes versus depressive episodes (at a ratio of approximately 10:1). Her illness started at the age of 19 years and was characterised by psychotic mania along with classic manic symptoms. She showed reluctance towards formal treatment for about 3 years. Therefore, a primary treatment was initiated with a series of antipsychotics and antidepressants including haloperidol and citalopram, which were marginally tolerable and successful. Subsequently, she received lithium for stabilisation. However, due to non-adherence, her treatment was switched to lamotrigine. She developed Stevens-Johnson syndrome due to lamotrigine. The woman once again received lithium at non-therapeutic dose for re-stabilisation; however, it was not successful in controlling a rapid cycling state. During re-evaluation, she expressed her intent to conceive along with the necessity of stabilisation of her illness. Her therapy was cross-tapered from lithium onto lurasidone. Consequently, she experienced good mood stability and euthymia that lasted for about 7 months. However, she was unable to conceive for several years. Therefore, she started receiving letrozole to aid in ovulation and pregnancy. Three weeks into letrozole therapy, she experienced manic episode, which she described as ’unlike anything’ she had developed before. The current manic episode was of longer duration than her previous manic episodes. She experienced disorganised thoughts, sleeplessness and increased impulsivity. Schneider AL. A case of letrozole induced mania. Bipolar Disorders : no pagination, Jan 2020. Available from: URL: http://doi.org/10.1111/bdi.13008

0114-9954/20/1830-0001/$14.95 Adis © 2020 Springer Nature Switzerland AG. All rights reserved

803514609

Reactions 14 Nov 2020 No. 1830