Lansoprazole
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Collagenous colitis in an elderly patient: case report A 77-year-old man developed collagenous colitis following long-term lansoprazole therapy for gastrooesophageal reflux disease. The man, who had been receiving lansoprazole [dosage not stated] for 6 years, was admitted to hospital due to watery diarrhoea, 5-10 bowel movements/day for 2 months and a 4 kg weight loss. He had previously taken clarithromycin for 2 weeks for bronchitis, 3 months after which he had developed watery diarrhoea. Tests for Clostridium difficile toxin and other pathogenic bacteria were negative. Colonoscopy showed the absence of vascular networks and many red spots in the sigmoid colon and descending colon. Biopsies revealed erosion with severe inflammation. Masson’s trichrome staining demonstrated subepithelial collagen bands as thick as 25µm. These findings were consistent with collagenous colitis. Lansoprazole therapy was suspended, and within a few days, the watery diarrhoea had disappeared. A second colonoscopy performed 2 months following lansoprazole suspension showed a reduction in the number of red spots. Masson’s trichrome staining of the specimens from the sigmoid colon revealed diminished collagen bands on haematoxylin-eosin staining, with faint bands as thin as 9µm. Sawada K, et al. Collagenous colitis appeared after 6-year administration of lansoprazole. Clinical Journal of Gastroenterology 3: 18-21, No. 1, Feb 2010. Available from: URL: http://dx.doi.org/10.1007/s12328-009-0126-4 803013769 Japan
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Reactions 15 May 2010 No. 1301
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