Laparoscopic versus open approach in gastrectomy for advanced gastric cancer: a systematic review
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(2020) 18:126
REVIEW
Open Access
Laparoscopic versus open approach in gastrectomy for advanced gastric cancer: a systematic review Zhipeng Zhu1†, Lulu Li1†, Jiuhua Xu2, Weipeng Ye2, Junjie Zeng1, Borong Chen1 and Zhengjie Huang1,2*
Abstract Background: Additional studies comparing laparoscopic gastrectomy (LG) versus open gastrectomy (OG) for advanced gastric cancer (AGC) have been published, and it is necessary to update the systematic review of this subject. Objective: We conducted the meta-analysis to find some proof for the use of LG in AGC and evaluate whether LG is an alternative treatment for AGC. Method: Randomized controlled trials (RCT) and high-quality retrospective studies (NRCT) compared LG and OG for AGC, which were published in English between January 2010 and May 2019, were search in PubMed, Embase, and Web of Knowledge by three authors independently and thoroughly. Some primary endpoints were compared between the two groups, including intraoperative time, intraoperative blood loss, harvested lymph nodes, first flatus, first oral intake, first out of bed, post-operative hospital stay, postoperative morbidity and mortality, rate of disease recurrence, and 5-year over survival (5-y OS). Besides, considering for this 10-year dramatical surgical material development between 2010 and 2019, we furtherly make the same analysis based on recent studies published between 2016 and 2019. Result: Thirty-six studies were enrolled in this systematic review and meta-analysis, including 5714 cases in LAG and 6094 cases in OG. LG showed longer intraoperative time, less intraoperative blood loss, and quicker recovery after operations. The number of harvested lymph nodes, hospital mortality, and tumor recurrence were similar. Postoperative morbidity and 5-y OS favored LG. Furthermore, the systemic analysis of recent studies published between 2016 and 2019 revealed similar result. Conclusion: A positive trend was indicated towards LG. LG can be performed as an alternative to OG for AGC. Keywords: Systematic review, Meta-analysis, Gastrectomy, Laparoscopy, Advanced gastric cancer
* Correspondence: [email protected] † Zhipeng Zhu and Lulu Li contributed equally to this work. 1 Department of Gastrointestinal Surgery, Xiamen Cancer Center, The First Affiliated Hospital of Xiamen University, 55 Zhen Hai Road, Si Ming District, Xiamen 361003, Fujian, People’s Republic of China 2 Department of Clinical Medicine, Fujian Medical University, Fuzhou 350004, Fujian, People’s Republic of China © The Author(s). 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit lin
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