Left ventricular function, morphology, and myocardial tissue characterization in Sickle Cell Disease: a multi-modality i
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POSTER PRESENTATION
Open Access
Left ventricular function, morphology, and myocardial tissue characterization in Sickle Cell Disease: a multi-modality imaging study Ahmad Homaa1*, Ankit A Desai2, Roberto M Lang1, Thejasvi Thiruvoipati1, Kristen Turner3, Lynn Weinert1, E Bruce Jamison1, Nicole Artz3, Sharon Trevino2, Sharon Feehan1, Roberto Machado2, Joe GN Garcia2, Amit R Patel1 From 2011 SCMR/Euro CMR Joint Scientific Sessions Nice, France. 3-6 February 2011 Objectives Our aim was to characterize the cardiac morphology, function and myocardium in patients with sickle cell disease (SCD) using CMR and transthoracic echocardiography (TTE). Background Cardiovascular complications are a major cause of death in SCD yet the mechanism remains unclear. Methods Thirty-one stable, African-American outpatients with SCD (mean age 32±8 yrs) prospectively underwent CMR (Philips 1.5 Tesla) and TTE (Philips iE33). Retrospectivelygated cines of left ventricular (LV) 2-, 3-, and 4-chamber, and short axis cine stack were obtained using SSFP (temporal resolution 25-40ms). Late gadolinium enhancement (LGE) images of the same views were obtained 10-20 minutes after infusion of Gd-DTPA (0.15 mmol/kg) using phase sensitive inversion recovery (TR 4.5 ms, TE 2.2ms, TI 250-300 ms, flip angle 30°, PSIR flip angle 5°). Single short-axis, mid-ventricular myocardial T2* slice and coronal, hepatic T2* slice were acquired with a single breath-hold, at six echo-times (2.3 to 14 msec) using a gradient echo sequence. Tissue T2* signal intensity was measured in LV septum and liver at two separate echo times and T2*= - ΔTE/ln (SI TE2 / SI TE1 ) where ΔTE represents time difference between the two echo times and I TE1 and I TE2 represent signal intensity at
1 University of Chicago Medical Center, Chicago, IL, USA Full list of author information is available at the end of the article
echo time one and two. Myocardial and hepatic T2* were abnormal if
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