• PDF / 170,240 Bytes
• 1 Pages / 595.245 x 841.846 pts (A4) Page_size
• 40 Downloads / 147 Views

DOWNLOAD

REPORT

---

1

S

Various toxicities: case report A 69-year-old woman developed vomiting, hair loss and thrombocytopenia during treatment with sorafenib for hepatocellular carcinoma. Later, she developed hypertension, hand-foot syndrome and anorexia during treatment with lenvatinib and nivolumab. The woman was diagnosed with hepatocellular carcinoma in September 2018. From 11 September–18 September, she received treatment with sorafenib. However, she developed treatment related vomiting, hair loss and thrombocytopenia. Later, the woman was transferred to the department of liver surgery. On 26th September 2018, a CT scan showed a large round-like mixed density mass in the liver. Hence, on 28th September 2018, she started receiving adjuvant chemotherapy with oral lenvatinib 8mg daily along with IV nivolumab injection 140mg every two weeks. A lesion was observed on the liver again on 15th March 2019, and she underwent an extended right hepatectomy and cholecystectomy on 25th March 2019. The surgery was successful, and her lenvatinib and nivolumab therapies were continued after the procedure. Improvement was noted in her underlying condition and her AFP levels reduced significantly. During the course of the treatment, she developed hypertension, hand-foot syndrome and anorexia secondary to the adjuvant chemotherapy, which were well controlled. Author comment: "After failing to take TACE treatment on September 11, 2018, she took sorafenib from September 11th to 18th. During the medication, she developed vomiting, hair loss, and thrombocytopenia". "Adverse events included handfoot syndrome, hypertension, and anorexia, but these were well controlled." Chen X, et al. Lenvatinib combined nivolumab injection followed by extended right hepatectomy is a feasible treatment for patients with massive hepatocellular carcinoma: A case report. OncoTargets and Therapy 12: 7355-7359, Sep 2019. 803431740 Available from: URL: http://doi.org/10.2147/OTT.S217123 - China

0114-9954/19/1778-0001/$14.95 Adis © 2019 Springer Nature Switzerland AG. All rights reserved

Reactions 9 Nov 2019 No. 1778