Leukocyte Integrins in the Immune System and Malignant Disease
Most lymphocytes recirculate throughout the body, migrating from blood through organized lymphoid tissues such as lymph nodes (LN) and Peyer's patches (PP), then to lymph and back to blood (GOWANS and KNIGHT 1964). Smaller numbers of lymphocytes migrate f
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Editors R.W. Compans, Atlanta/Georgia M. Cooper, Birmingham/Alabama J.M. Hogle, Boston/Massachusetts· Y. Ito, Kyoto H. Koprowski, Philadelphia/Pennsylvania· F. Me1chers, Basel M. Old stone, La Jolla/California· S. Olsnes, Oslo M. Potter, Bethesda/Maryland· H. Saedler, Cologne P.K. Vogt, La Jolla/California· H. Wagner, Munich
Springer Berlin Heidelberg New York Barcelona Budapest Hong Kong London Milan Paris Santa Clara Singapore Tokyo
Leukocyte Integrins in the Immune System and Malignant Disease Edited by B. Holzmann and H. Wagner
With 40 Figures
Springer
Professor Bernhard HOLZMANN, M.D. Professor Hermann WAGNER, M.D., Ph.D. Technical University of Munich Institute of Medical Microbiology, Immunology, and Hygiene Trogerstr. 9 0-81675 Munich Germany
Cover illustration: Cell adhesion receptors of the integrin family are important elements of cellular communication. The capacity of integrins to bind ligand is rapidly regulated by cellular signaling events that alter integrin conformation and clustering. Upon recognition and binding of cognate ligands integrins may also function as signal transduction devices that affect cellular responses to environmental signals. Cover design: design & production GmbH, Heidelberg
ISSN 0070-217X ISBN-13:978-3-642-71989-9 e-ISBN-13: 978-3-642-71987-5 001: 10.1007/978-3-642-71987-5 This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilm or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permission for use must always be obtained from Springer-Verlag. Violations are liable for prosecution under the German Copyright Law. Springer-Verlag Berlin Heidelberg 1998 Softcover reprint of the hardcover 1st edition 1998 Library of Congress Catalog Card Number 15-12910 The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. (C)
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List of Contents
C. MORIMOTO, S. IWATA, and K. TACHIBANA VLA-4-Mediated Signaling . . . . . . . . . . . . . . . . . . . . . . . N. WAGNER and W. MOLLER Functions of ot4-~7-Integrins in Hematopoiesis, Lymphocyte Trafficking and Organ Development. . . . . ..
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W. KOLANUS and L. ZEITLMANN Regulation of Integrin Function by Inside-Out Signaling Mechan
