Life-Span Extension Single-Cell Organisms to Man
In recent years, remarkable discoveries have been made concerning the underlying mechanisms of aging. In Life-Span Extension: Single-Cell Organisms to Man, the editors bring together a range of illuminating perspectives from researchers investigating the
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Life-Span Extension Single-Cell Organisms to Man
Edited by
Christian Sell, PhD
Department of Pathology and Laboratory Medicine Drexel University College of Medicine, Philadelphia, PA, USA
Antonello Lorenzini, PhD
Department of Pathology, and Laboratory Medicine Drexel University College of Medicine, Philadelphia, PA, USA
Holly M. Brown-Borg, PhD
Department of Pharmacology, Physiology and Therapeutics School of Medicine and Health Sciences, University of North Dakota Grand Forks, ND, USA
Editors Christian Sell Antonello Lorenzini Department of Pathology Department of Pathology and Laboratory Medicine and Laboratory Medicine Drexel University Drexel University College of Medicine College of Medicine Philadelphia, PA Philadelphia, PA USA USA Holly M. Brown-Borg Department of Pharmacology, Physiology and Therapeutics School of Medicine and Health Sciences University of North Dakota Grand Forks, ND USA
ISBN: 978-1-60327-506-4 e-ISBN: 978-1-60327-507-1 DOI 10.1007/978-1-60327-507-1 Springer Dordrecht Heidelberg London New York Library of Congress Control Number: 2009922206 © Humana Press, a part of Springer Science+Business Media, LLC 2009 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Humana Press, c/o Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. Cover illustration: Christian Sell, PhD Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Preface
This volume contains viewpoints of investigators studying the aging process in species ranging from yeast to man. The effort to compile these viewpoints has been driven by recent, remarkable discoveries about the underlying mechanisms important to aging. Single mutations that extend life span have been identified in yeast, worms, flies, and mice. Studies in humans have identified potentially important markers for successful aging. The genes and pathways identified in these studies involve a surprisingly small set of conserved functions, most of which have been the focus of aging research for some time. For example, recent genome-wide analyses of genes involved in life-span extension that are common to yeast and Caenorhabditis elegans identified a regulator of protein synthesis, the mTOR pathway, which leads to transcriptional control as a common longevity pathway in these two organisms. In mammals, this pathwa
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