Lipid-dendrimer nanohybrid system or dendrosomes: evidences of enhanced encapsulation, solubilization, cellular uptake a
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ORIGINAL ARTICLE
Lipid‑dendrimer nanohybrid system or dendrosomes: evidences of enhanced encapsulation, solubilization, cellular uptake and cytotoxicity of bortezomib Vinay Kumar1 · Iliyas Khan1 · Umesh Gupta1 Received: 8 May 2020 / Accepted: 11 July 2020 © King Abdulaziz City for Science and Technology 2020
Abstract Dendrimers are proven solubilizers of hydrophobic as well as hydrophilic drugs in its internal architecture. However, the toxicity of cationic dendrimers restricts its future possibilities as successful formulation. Hybrid systems such as lipid-dendrimer have shown great potential as drug delivery system due to their multifunctional adjustability, and biocompatibility. In the present study, liposomal dendrimer based nano-hybrid (called dendrosomes) of BTZ (bortezomib) were prepared and characterized through time-dependent transmission electron microscope (TEM) as well as photon correlation spectroscopy. Two types of prepared dendrosomes (DS1 and DS2) exhibited size of 145 ± 2.69 and 147 ± 3.26 nm, respectively. The overall hemolytic toxicity of the developed DS1 and DS2 dendrosomes was 4.96 ± 0.45 and 3.19 ± 0.32% (p
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