Lipidic nanomaterials to deliver natural compounds against cancer: a review
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REVIEW
Lipidic nanomaterials to deliver natural compounds against cancer: a review Vishal Sharad Chaudhari1 · Upadhyayula Suryanarayana Murty2 · Subham Banerjee1 Received: 15 May 2020 / Accepted: 19 June 2020 © Springer Nature Switzerland AG 2020
Abstract Many diseases such as cancer are cured by natural substances, yet practical applications are limited by low pharmacodynamics due to poor solubility and permeability, photosensitivity, chemical instability, and first-pass metabolism. These issues are partly solved by nanotechnology. Here, we review briefly lipid-based nanomaterials for drug delivery. Indeed, lipid nanoconstructs allow active and passive targeting, biocompatibility, improved safety, and efficacy. Lipid nanoconstructs include both vesicular- and particulate-based systems such as liposomes, lipid micelles, solid lipid nanoparticles, and nanostructured lipid carriers. Keywords Natural products · Lipid nanoconstructs · Cancer · Improved delivery
Introduction Nature acquires an arsenal of therapeutically significant molecules against multiple ailments (Newman and Cragg 2016). Not only age-old traditional practices (Buenz et al. 2018) but also the modern drug discovery arena largely depends on natural chemical moieties (Du 2018). Categorically, natural products are alkaloids, glycosides, saponins, terpenoids, phenolics, and these molecules carry out most of the therapeutic activities in our physiology (Springob and Kutchan 2009). In general, naturally occurring anticancer molecules are obtained by microbes, plants or marine sources (Demain and Vaishnav 2011; Tewari et al. 2019). The combination of natural products most often shows additive or synergistic effects against cancer (Farooq et al. 2019). Natural molecules have shown promising anticancer properties in a laboratory scale. Despite such considerable results, properties like poor solubility, narrow therapeutic window, inferior absorption rate, and lower bioavailability, as well as stability issues, have halted the use of bare molecules or common formulations. As per many studies, these * Subham Banerjee [email protected] 1
Department of Pharmaceutics, National Institute of Pharmaceutical Education & Research (NIPER)Guwahati, Changsari, Kamrup, Assam 781 101, India
NIPER-Guwahati, Changsari, Kamrup, Assam 781 101, India
2
formulations were also appeared to possess inappropriate pharmacokinetic profile and reduced elimination half-life, resulting in compromised activity as its consequences (Xie et al. 2016). Nanoformulations were found to possess amicable construct, surface property, lower side effects, and improved pharmacokinetic property when compared with preceding formulations. Nanoparticles are defined as particles ranging from 1 to 100 nm in its dimension (Watkins et al. 2015). Tailormade approaches like nanoformulation constructs result in improvement of the amicable pharmacokinetic profile, reduced side effects, and superior surface area-to-volume ratio as its consequences (Kakkar et al. 2018). Various types of nanoca
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