Live birth rate from euploid blastocysts is not associated with infertility etiology or oocyte source following frozen-t
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ASSISTED REPRODUCTION TECHNOLOGIES
Live birth rate from euploid blastocysts is not associated with infertility etiology or oocyte source following frozen-thawed embryo transfer (FET): analysis of 4148 cycles reported to SART CORS F. Meng 1 & M. Goldsammler 2,3
&
E. Wantman 4 & E. Buyuk 2,5 & S. K. Jindal 2,3
Received: 8 June 2020 / Accepted: 26 October 2020 # Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Purpose To investigate whether live birth rates from euploid blastocyst frozen-thawed embryo transfer (FET) cycles are associated with infertility diagnosis or oocyte source. Design Retrospective analysis of FET cycles reported to SART CORS in 2014. Methods Data from fresh IVF cycles with preimplantation genetic testing for aneuploidy (PGT-A), linked to the first FET cycles, were collected from the 2014 SART CORS database for autologous and donor oocyte cycles. Inclusion criteria were patients undergoing FET with euploid embryos (n = 4148). Demographic data including age, BMI, prior fertility, and etiology of infertility were collected from the retrieval cycle and analyzed. Patients with uterine anomalies, preimplantation genetic testing-mutation (PGT-M) for genetic diseases, gender selection, HLA determination, or systemic and immunologic disorders were excluded. The primary outcome measure was live birth (LB) rate. Potential confounders such as age, prior fertility, and maximum baseline FSH values were analyzed with regression models as indicated. Results Though age, maximum baseline FSH, and infertility diagnosis were significantly different, LB was similar between patients undergoing autologous or donor oocyte FET cycles. Etiology of infertility was not significantly associated with LB in autologous cycles (p = 0.95). Potential confounders such as maternal age, prior fertility, and maximum baseline FSH were not associated with outcomes; however, maternal BMI was inversely related to LB in autologous cycles, with an odds ratio of 0.97 (95% CI: 0.96–0.98 (rho = − 0.08, p < 0.01)). Conclusions After controlling for confounding variables, a euploid embryo derived from a donor or autologous oocyte results in similar LB in women with different infertility diagnoses. Keywords Euploid . Live birth rate . Infertility . Frozen embryo transfer
Introduction F. Meng and M. Goldsammler share first authorship equally. * M. Goldsammler [email protected] 1
OC Fertility Center, Newport Beach, CA 92604, USA
2
Obstetrics & Gynecology and Women’s Health, Albert Einstein College of Medicine, Bronx, NY, USA
3
Montefiore’s Institute for Reproductive Medicine and Health, 141 S. Central Ave, Hartsdale, NY 10530, USA
4
Redshift Technologies, New York, NY, USA
5
Present address: Reproductive Medicine Associates of New York, Obstetrics, Gynecology and Reproductive Science, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Transferring euploid embryos is one key for successful implantation and live birth following in vitro fertilization (IVF) treatment. Chromosomal abnormalities a
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