Liver resection for young patients with large hepatocellular carcinoma: a single center experience from China
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WORLD JOURNAL OF SURGICAL ONCOLOGY
RESEARCH
Open Access
Liver resection for young patients with large hepatocellular carcinoma: a single center experience from China Xi-yu Liu and Jiang-feng Xu*
Abstract Background: To investigate retrospectively the clinicopathological characteristics and outcomes of young patients with large hepatocellular carcinoma after hepatectomy. Methods: From January 2003 to December 2012, a total of 153 patients with large hepatocellular carcinoma (HCC) who received liver resection were included in the study. The clinicopathological features were analyzed retrospectively. The perioperative data were compared between those aged 40 years (the older group). Prognostic factors and long-term survival were evaluated. Results: The young group had more hepatitis B virus-related HCC than the older group (87.2% vs 66.3%, P = 0.031). In the young group, 15 patients (21.5%) were overweight (body mass index 25 to 29.9 kg/m2) or obese (body mass index ≥30 kg/m2), and 38 patients (45.8%) were overweight or obese in the older group (P = 0.032). Other clinicopathological characteristics were similar between the two groups. The perioperative data showed that the older group had more pulmonary infection after hepatectomy. Vascular invasion and high Edmondson-Steiner grade were the independent prognostic factors for long-term survival. There was no statistical difference between the young group and the older group in overall survival and disease-free survival (P = 0.109 and P = 0.087, respectively). Conclusions: Liver resection for young patients with large HCC was safe and efficacious and should be recommended. Keywords: Liver resection, Young patients, Large hepatocellular carcinoma
Background Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide, especially in China. HCC ranks second as a cause of cancer death overall in China [1-4]. Many studies have reported that hepatectomy could be performed satisfactorily for large HCC (>5 cm) with acceptable mortality [5-7]. However, there are few reports about the clinicopathological features and outcomes in young patients with large HCC after hepatectomy, and the significance of hepatectomy for these patients therefore remains unknown. In USA and Europe, which are not hepatitis B endemic areas, patients younger than 40 years of age with large HCC are reported to be rare;however, young patients with * Correspondence: [email protected] Department of surgery, Yiwu Affiliated Hospital of Zhejiang University School of Medicine, east building in huajiachi campus,kaixuan road 268, 310020 Hangzhou, Zhejiang, China
large HCC are not uncommon in China. To investigate the clinicopathological features as well as the long-term outcomes after hepatectomy of young patients with large HCC, we performed a retrospective study of patients with large HCC undergoing hepatectomy whose ages were younger than 40 years (the young group), compared to those patients aged above 40 years (the older group).
Methods From January 2003 to December 2012, 153
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