Long Non-Coding RNAs
Long non-coding RNAs (lncRNAs), tentatively defined as ncRNAs of more than two hundred nucleotides in length, are characterized by the complexity and diversity of their sequences and mechanisms of action. Based on genome-wide studies, more than 3,300 of t
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Volumes Published in the Series Progress in Molecular and Subcellular Biology
Subseries: Marine Molecular Biotechnology
Volume 35 RNA Trafficking and Nuclear Structure Dynamics Ph. Jeanteur (Ed.)
Volume 37 Sponges (Porifera) W.E.G. Mu¨ller (Ed.)
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- Ugarkovic´ Ðurdica Editor
Long Non-Coding RNAs
Editor - Ugarkovic´ Ðurdica - Bosˇkovic´ Institute Ruder Bijenicˇka 54 10001 Zagreb P.O. Box 1016 Croatia
ISSN 0079-6484 ISBN 978-3-642-16501-6 e-ISBN 978-3-642-16502-3 DOI 10.1007/978-3-642-16502-3 Springer Heidelberg Dordrecht London New York # Springer-Verlag Berlin Heidelberg 2011 This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilm or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permission for use must always be obtained from Springer. Violations are liable to prosecution under the German Copyright Law. The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Cover design: SPi Publisher Services Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Preface
A major portion of the eukaryotic genome is occupied by DNA sequences whose transcripts do not code for proteins. This part of eukaryotic genome is transcribed in a developmentally regulated manner or as a response to external stimuli to produce large numbers of long noncoding RNAs (lncRNAs). Genome-wide studies indicate existence of more than 3,300 lncRNAs. Long ncRNAs are tentatively defied as molecules of ncRNA more than two hundred nucleotides long. Due to the complexity and diversity of their sequences and their mechanisms of
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