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Stefan Jurga Jan Barciszewski Editors

The Chemical Biology of Long Noncoding RNA s

RNA Technologies Volume 11 Series Editors Jan Barciszewski, Nanobiomedical Center, Adam Mickiewicz University, Poznań, Poland Institute of Bioorganic Chemistry of the Polish, Academy of Sciences, Poznań, Poland Nikolaus Rajewsky, Max Delbrück Center for Molecular Medicine, Berlin Institute for Medical Systems Biology, Berlin-Buch, Berlin, Germany Founding Editors Volker A. Erdmann, Institute of Chemistry and Biochemistry, Free University of Berlin, Berlin, Germany Jan Barciszewski, Nanobiomedical Center, Adam Mickiewicz University, Poznań, Poland Institute of Bioorganic Chemistry of the Polish, Academy of Sciences, Poznań, Poland

More information about this series at http://www.springer.com/series/8619

Stefan Jurga • Jan Barciszewski Editors

The Chemical Biology of Long Noncoding RNAs

Editors Stefan Jurga Nanobiomedical Center of the Adam Mickiewicz University, Poznań, Poland

Jan Barciszewski Nanobiomedical Center of the Adam Mickiewicz University, Poznań, Poland Institute of Bioorganic Chemistry of the Polish Academy of Sciences, Poznań, Poland

ISSN 2197-9731 ISSN 2197-9758 (electronic) RNA Technologies ISBN 978-3-030-44742-7 ISBN 978-3-030-44743-4 (eBook) https://doi.org/10.1007/978-3-030-44743-4 © Springer Nature Switzerland AG 2020 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, expressed or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Switzerland AG. The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland

Preface

Introduction Long Non-protein Coding RNAs Over the last few decades the development of high-throughput technologies has changed the perception of the Crick’s Central Dogma of Molecular Biology stating that genetic information inscribed in DNA is transcribed into RNA and afterwards translated into proteins (Fig.