Long-term outcome of cervical artery dissection
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ORIGINAL ARTICLE
Long-term outcome of cervical artery dissection IPSYS CeAD: study protocol, rationale, and baseline data of an Italian multicenter research collaboration Sonia Bonacina 1 & Mario Grassi 2 & Marialuisa Zedde 3 & Andrea Zini 4 & Anna Bersano 5 & Carlo Gandolfo 6 & Giorgio Silvestrelli 7 & Claudio Baracchini 8 & Paolo Cerrato 9 & Corrado Lodigiani 10 & Simona Marcheselli 11 & Maurizio Paciaroni 12 & Maurizia Rasura 13 & Manuel Cappellari 14 & Massimo Del Sette 15 & Anna Cavallini 16 & Andrea Morotti 17 & Giuseppe Micieli 18 & Enrico Maria Lotti 19 & Maria Luisa DeLodovici 20 & Mauro Gentile 4 & Mauro Magoni 21 & Cristiano Azzini 22 & Maria Vittoria Calloni 23 & Elisa Giorli 24 & Massimiliano Braga 25 & Paolo La Spina 26 & Fabio Melis 27 & Rossana Tassi 28 & Valeria Terruso 29 & Rocco Salvatore Calabrò 30 & Maurizio Melis 31 & Maria Sessa 32 & Martina Locatelli 1 & Sandro Sanguigni 33 & Carla Zanferrari 34 & Marina Mannino 35 & Giuseppina Calabrese 36 & Carlo Dallocchio 37 & Patrizia Nencini 38 & Valeria Bignamini 39 & Alessandro Adami 40 & Eugenio Magni 41 & Rita Bella 42 & Alessandro Padovani 1 & Alessandro Pezzini 1 & the Italian Project on Stroke in Young Adults – Cervical Artery Dissection (IPSYS CeAD) Research Group Received: 21 March 2020 / Accepted: 7 May 2020 # Fondazione Società Italiana di Neurologia 2020
Abstract Long-term consequences of cervical artery dissection (CeAD), a major cause of ischemic stroke in young people, have been poorly investigated. The Italian Project on Stroke at Young Age – Cervical Artery Dissection (IPSYS CeAD) project is a multicenter, hospital-based, consecutively recruiting, observational, cohort study aimed to address clinically important questions about long-term outcome of CeAD patients, which are not covered by other large-scale registries. Patients with radiologically diagnosed CeAD were consecutively included in the registry. Baseline demographic and clinical variables, as well as information on risk factors, were systematically collected for each eligible patient. Follow-up evaluations were conducted between 3 and 6 months after the initial event (t1) and then annually (t2 at 1 year, t3 at 2 years , and so on), in order to assess outcome events (long-term recurrent CeAD, any fatal/ nonfatal ischemic stroke, transient ischemic attack (TIA), or other arterial thrombotic event, and death from any cause). Between 2000 and 2019, data from 1530 patients (age at diagnosis, 47.2 ± 11.5 years; women, 660 [43.1%]) have been collected at 39 Italian neurological centers. Dissection involved a single vessel in 1308 (85.5%) cases and caused brain ischemia in 1303 (85.1%) (190 TIA/1113 ischemic stroke). Longitudinal data are available for 1414 (92.4%) patients (median follow-up time in patients who did not experience recurrent events, 36.0 months [25th to 75th percentile, 63.0]). The collaborative IPSYS CeAD effort will provide novel information on the long-term outcome of CeAD patients. This could allow for tailored treatment approaches based on patients’ individual c
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