Loperamide
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Various toxicities: case report A 30-year-old man developed generalised tonic clonic seizure, QTc interval prolongation, recurrent ventricular tachycardia and recurrent ventricular fibrillation following abuse and overdose of loperamide. The man, who had a history of epilepsy, presented with generalised tonic clonic seizures. He got intubated in emergency department secondary to low glasgow coma scale. Initially, treatment initiated for status epileptics with 4 antiepileptic drugs, but electroencephalogram was unremarkable. Later, he developed QTc interval prolongation. On anamnesis, abuse of loperamide with 100–120 tablets per day [route and dose not stated] was revealed. During the hospitalisation, he developed recurrent ventricular tachycardia and recurrent ventricular fibrillation [duration of treatment to reaction onset not stated]. The man’s treatment was supported by manual cardiopulmonary resuscitation, standard advanced cardiac life support and temporary pacemaker, which was applied and got reverted back. Fayyaz S, et al. Loperamide abuse associated with cardiac dysrhythmia: Case report. European Journal of Emergency Medicine: Official Journal of the European Society for 803520297 Emergency Medicine 27 (Suppl.): e12 abstr. 191, Sep 2020. Available from: URL: http://doi.org/10.1097/01.mej.0000697860.10490.3d [abstract]
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Reactions 12 Dec 2020 No. 1834
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