Lymphoma and Leukemia of the Nervous System
Lymphomas and leukemias of the nervous system result in devastating neurological complications and high mortality. These malignancies may arise within the central nervous system or may disseminate to the brain or cerebrospinal fluid from a source elsewher
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Tracy Batchelor · Lisa M. DeAngelis Editors
Lymphoma and Leukemia of the Nervous System
Foreword by James O. Armitage and Franco Cavalli
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Editors Tracy Batchelor Stephen E. and Catherine Pappas Center for Neuro-Oncology Departments of Neurology and Radiation Oncology Division of Hematology and Oncology Massachusetts General Hospital Harvard Medical School 55 Fruit Street Boston, MA 02114, USA [email protected]
Lisa M. DeAngelis Department of Neurology Memorial Sloan-Kettering Cancer Center 1275 York Avenue New York, NY 10021-6007, USA [email protected]
ISBN 978-1-4419-7667-3 e-ISBN 978-1-4419-7668-0 DOI 10.1007/978-1-4419-7668-0 Springer New York Dordrecht Heidelberg London Library of Congress Control Number: 2011928786 1st edition: © Elsevier Limited 2004 2nd edition: © Springer Science+Business Media, LLC 2012 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. While the advice and information in this book are believed to be true and accurate at the date of going to press, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Foreword
A major step in learning to treat any disease is the ability to place patients into groups that are similar clinically, biologically, and in response to therapy. In a complex group of diseases like the immune system malignancies, this is absolutely vital if we are to develop effective therapies for each subgroup. The history of the management of patients with lymphoma is a story of our ability to understand and coherently group these tumors. This work began at the start of the twentieth century with the recognition of the Reed Sternberg cell (i.e. dividing what we now call Hodgkin lymphoma from the other lymphomas), and has continued through new histological classifications, immune studies, and, more recently, genetic studies including gene expression arrays. Over the years, it has become clear that lymphomas originating in certain, perhaps all, extranodal sites have unique characteristics and might require specific treatment approaches. This is true even though we do not always understand the biological explanation for the
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