Macrophage-Specific Gene Targeting In Vivo
The study of macrophage biology has been hindered by our inability to efficiently direct transgene expression to cells of the mononuclear phagocyte lineage in vivo. Recent progress in understanding the transcriptional regulation of several genes expressed
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Volume 158 Editor-in-Chief K. Starke, Freiburg i. Br. Editorial Board G. V. R. Born, London M. Eichelbaum, Stuttgart D. Ganten, Berlin H. Herken t, Berlin F. Hofmann, Miinchen 1. Limbird, Nashville, TN w. Rosenthal, Berlin G. Rubanyi, Richmond, CA
Springer-Verlag Berlin Heidelberg GmbH
The Macrophage as Therapeutic Target Contributors J. M. Aerts, R. Boot, E.J. Brown, G.D. Brown, P.C. Calder, T. J. Chambers, W. J. S. de Villiers, F. Di Virgilio, M. G. Espey, D. Ferrari, A. Frauenschuh, T. Ganz, C. K. Glass, S. Gordon, D.R. Greaves, A. Groener, D.N.J. Hart, P.M. Henson, S.R. Himes, C. Hollak, D.A. Hume, Z. Johnson, G. Kraal, R.I. Lehrer, J.D. MacMicking, J. Mahoney, L. Martinez-Pomares, J.D. McKinney, J.L. Miller, S. M. Moghimi, V. H. Perry, A. Proudfoot, H. Rosen, D.R. van der Westhuyzen, N. van Rooijen, S. Vuckovic, J.S. Welch, J.A. Willment, S. Wong, P. Yaqoob Editor
Siamon Gordon
Springer
Professor Siamon Gordon Sir William Dunn School of Pathology University of Oxford South Parks Road Oxford OXl 3RE United Kingdom e-mail: [email protected]
With 27 Figures and 9 Tables ISBN 978-3-642-62919-8 ISBN 978-3-642-55742-2 (eBook) DOI 10.1007/978-3-642-55742-2 Cataloging-in-Publication Data applied for Bibliographic infonnation published by Die Deutsche Bibliothek Die Deutsche Bibliothek lists this publication in the Nationalbibliografie; detailed bibliographic data is available in the Internet at . This work is subject to copyright. AU rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, re-use of illustrations, recitation, broadcasting, reproduction on microfilm or in any other way, and storage in data banks. Duplication ofthis publication or parts thereof is permitted only under the provisions of the Gennan Copyright Law of September 9, 1965, in its current version, and pennission for use must always be obtained from SpringerVerlag. Violations are liable for Prosecution under the German Copyright Law. © Springer-Verlag Berlin Heidelberg 2003 Softcover reprint of the hardcover Ist edition 2003 The use of general descriptive names, registered names, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and free for general use. Product liability: The publishers cannot guarantee the accuracy of any infonnation about dosage and application contained in this book. In every individual case the user must check such information by consulting the relevant literature. Cover design: design & production GmbH, Heidelberg Typesetting: Stiirtz AG, 97080 Wiirzburg 27/3150 hs - 5 4 3 2 1 O
Preface
During the past decade, the rapid growth of molecular and cellular knowledge of macrophages (M0), as a specialized host defence and homeostatic system, has begun to offer attractive targets for therapeutic intervention. M0 playa central role in a wide range of disease processes, from genetically determined lysosomal storage dise
