Macular capillary system and ganglion cell-layer complex of the amblyopic eye with optical cohorence tomography angiogra
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ORIGINAL PAPER
Macular capillary system and ganglion cell-layer complex of the amblyopic eye with optical cohorence tomography angiography and optical cohorence tomography F. G. Yilmaz Cinar
. G. Ozkan
Received: 30 April 2020 / Accepted: 7 October 2020 Ó Springer Nature B.V. 2020
Abstract Purpose To investigate the macular capillary system and ganglion cell-layer complex of the amblyopic eye with OCTA and OCT in comparison with fellow nonamblyopic eyes and a healthy control group and to examine their relationship with the severity of amblyopia. Methods This prospective, cross-sectional comparative study enrolled 25 amblyopic patients and 25 healthy controls. All patients and controls underwent OCTA and OCT imagining. Macular vessel densities of the Superficial Capillary Plexus (SCP) and Deep Capillary Plexus (DCP) and retinal thickness were measured by OCTA and ganglion cell layer (GCL) by OCT. Results SCP density at the fovea and parafovea was significantly lower in amblyopic eyes than in fellow eyes and control group. DCP density at the fovea was significantly lower in amblyopic eyes than fellow eyes and control group. Mean GCL thickness on OCT was 0.73 ± 0.07 lm in amblyopic eyes, 0.75 ± 0.06 lm in fellow eyes and 0.77 ± 0.06 lm in the control group. GCL volume was significantly lower in amblyopic eyes than the fellow eyes. The SCP and DCP and GCL thickness were not affected by the severity of amblyopia. F. G. Yilmaz Cinar (&) G. Ozkan Saglik Bakanligi Ankara Egitim ve Arastirma Hastanesi Altındag, Ankara, Turkey e-mail: [email protected]
Conclusion Macular vessel densities of the SCP and DCP of eyes with amblyopia is lower compared to the fellow non-amblyopic eyes and the control group. The thickness of GCL was lower in amblyopic eyes than fellow eyes while the severity of amblyopia did not have any impact on these structures. Microvascular retinal structures may have been affected in the course of amblyopia development. Keywords Optical cohorence tomography angiography Optical cohorence tomography Amblyopia Macular capillary system Ganglion celllayer complex
Introduction Amblyopia is the second most common cause of reduced vision in children after myopia and affects 1.6–3.6% of the population [1]. Although the pathophysiology of amblyopia has not been fully defined, functional changes during amblyopic development is reported to occur at various levels of the visual pathway [2]. Previous optical coherence tomography (OCT) studies have shown that the amblyopic process may be associated with retinal changes in amblyopic eyes [3–6]. Optical coherence tomography angiography (OCTA) is a noninvasive imagining technique that
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Int Ophthalmol
provides depth-resolved visualization of the retinal microvasculature. It allows quantitative analysis of the superficial retinal capillary plexus (SCP), deep retinal capillary plexus (DCP) and the choroid. The purpose of this study was to investigate the macular capillary system and ganglion cell-layer complex of
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