Magnetic resonance imaging of post-systolic shortening in a closed-chest rat model of coronary occlusion using myocardia
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POSTER PRESENTATION
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Magnetic resonance imaging of post-systolic shortening in a closed-chest rat model of coronary occlusion using myocardial tagging Stephany Gardier1*, Jean-Noel Hyacinthe1, Manuel Jorge-Costa2, Denis R Morel2, Jean-Paul Vallée1 From 2011 SCMR/Euro CMR Joint Scientific Sessions Nice, France. 3-6 February 2011
The aim of the study was to evaluate the reliability and sensitivity of tagged cardiac magnetic resonance imaging (cMRI) in assessment of regional cardiac dysfunction induced by short ischemia. For clinical low dose dobutamine tests, quantitative strain analyses derived from tagged cMRI have been shown to be able to detect viable myocardium. However these preliminary data were obtained in patients with high grade coronary stenosis, likely to have a large ischemic territory. So it is not known whether MRI tagging could detect coronary occlusion i) of short duration and ii) in small ischemic areas. A model of closed-chest coronary artery occlusion was developed in Sprague-Dawley rats. 10 rats underwent a 3 minutes coronary occlusion followed by 30 minutes of reperfusion, directly in a 1.5 Tesla clinical MRI scanner. Efficiency and reversibility of the coronary occlusion was assessed by modifications of the ECG recording. Tagged images were acquired every 2.5 minutes using C-SPAMM with segmented cine fast field echo sequence. Strain analysis was performed with the Extrema Temporal Chaining algorithm in six sectors of the short axis slice, classified in 2 groups: anterolateral and inferolateral sectors were considered as ischemic whereas inferior, inferoseptal and anteroseptal sectors were remote. Contraction (maximum strain) and contractility (strain rate) derived from the myocardial strain curves were analysed using a linear model. Eight rats underwent hemodynamic measurements by intraventricular catheterism to evaluate global cardiac function along a similar protocol of ischemia-reperfusion.
During the occlusion, contraction was reduced and delayed in the ischemic sectors compared to remote group (p
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