Main genetic differences in high-grade gliomas may present different MR imaging and MR spectroscopy correlates
- PDF / 8,842,063 Bytes
- 15 Pages / 595.276 x 790.866 pts Page_size
- 46 Downloads / 164 Views
MAGNETIC RESONANCE
Main genetic differences in high-grade gliomas may present different MR imaging and MR spectroscopy correlates Ángela Bernabéu-Sanz 1
&
María Fuentes-Baile 2 & Cristina Alenda 3
Received: 11 February 2020 / Revised: 8 June 2020 / Accepted: 3 August 2020 # European Society of Radiology 2020
Abstract Objective To assess whether the main genetic differences observed in high-grade gliomas (HGG) will present different MR imaging and MR spectroscopy correlates that could be used to better characterize lesions in the clinical setting. Methods Seventy-nine patients with histologically confirmed HGG were recruited. Immunohistochemistry analyses for isocitrate dehydrogenase gene 1 (IDH1), alpha thalassemia mental retardation X-linked gene (ATRX), Ki-67, and p53 protein expression were performed. Tumour radiological features were examined on MR images. Metabolic profile and infiltrative pattern were assessed with MR spectroscopy. MR features were analysed to identify imaging-molecular associations. The Kaplan-Meier method and the Cox regression model were used to identify survival prognostic factors. Results In total, 17.7% of the lesions were IDH1-mutated, 8.9% presented ATRX-mutated, 70.9% presented p53 unexpressed, and 22.8% had Ki-67 > 5%. IDH1 wild-type tumours had higher levels of mobile lipids (p = 0.001). The tumour-infiltrative pattern was higher in HGG with unexpressed p53 (p = 0.009). Mutated ATRX tumours presented higher levels of glutamate and glutamine (Glx) (p = 0.001). An association was observed between Glx tumour levels (p = 0.038) and Ki-67 expression (p = 0.008) with the infiltrative pattern. Survival analyses identified IDH1 status, age, and tumour choline levels as independent predictors of prognostic significance. Conclusions Our results suggest that IDH1-wt tumours are more necrotic than IDH1-mut. And that the presence of an infiltrative pattern in HGG is associated with loss of p53 expression, Ki-67 index, and Glx levels. Finally, tumour choline levels could be used as a predictive factor in survival in addition to the IDH1 status to provide a more accurate prediction of survival in HGG patients. Key Points • IDH1-wt tumours present higher levels of mobile lipids than IDH1-mut. • Mutated ATRX tumours exhibit higher levels of glutamate and glutamine. • Loss of p53 expression, Ki-67 expression, and glutamate and glutamine levels may contribute to the presence of an infiltrative pattern in HGG. Keywords Glioma . Isocitrate dehydrogenase . Magnetic resonance imaging . Magnetic resonance spectroscopy . Tumor suppressor protein p53 Electronic supplementary material The online version of this article (https://doi.org/10.1007/s00330-020-07138-4) contains supplementary material, which is available to authorized users. * Ángela Bernabéu-Sanz [email protected] 1
Magnetic Resonance Department, Hospital General Universitario de Alicante, Inscanner SL, C/ Pintor Baeza, 11, 03010 Alicante, Spain
2
Research Laboratory, Hospital General Universitario de Alicante, ISABIAL, Alicante, S
Data Loading...
