Management and Curation of Multi-Dimensional Data in Biobank Studies

The development of secure and reliable systems to collect, store, utilise, and share data on study participants plays a critical role in large population health studies. Contemporary prospective biobank studies typically involve hundreds of thousands of p

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Population Biobank Studies: A Practical Guide

Population Biobank Studies: A Practical Guide

Zhengming Chen Editor

Population Biobank Studies: A Practical Guide

Editor Zhengming Chen Nuffield Department of Population Health University of Oxford Oxford, Oxfordshire, UK

ISBN 978-981-15-7665-2 ISBN 978-981-15-7666-9 https://doi.org/10.1007/978-981-15-7666-9

(eBook)

© Springer Nature Singapore Pte Ltd. 2020 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, expressed or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Singapore Pte Ltd. The registered company address is: 152 Beach Road, #21-01/04 Gateway East, Singapore 189721, Singapore

Foreword

A large study is not just a small study made larger There can be few books into which the scientific editor has put more decades of epidemiological preparation than Zhengming Chen has into this book or at least into the study that it describes. Now Professor of Epidemiology at Oxford, he began doing epidemiological studies in China more than 30 years ago. He has continued ever since, working on studies in China from a UK base and building in the process the largest collaboration in the world between Chinese and Western randomised and observational studies of population health. Each new study has been considerably larger than its predecessors. Eventually, he and the team he had built up at Oxford were conducting, jointly with co-principal investigators and colleagues in China, rigorously randomised trials with several tens of thousands of participants of widely practicable treatments for common diseases. They were also conducting larger and larger observational epidemiological studies, culminating 15 years ago, as described in this book, in what was the world’s largest blood-based biobank study, with samples stored from half a million apparently healthy adults all over China, with electronic linkage to a