Management of Infections in the Immunocompromised Host
This book provides a comprehensive, state-of-the-art review of the concepts vital to a modern treatment of common and opportunistic infections in the immunocompromised host. Chapters are written by experts in the field, and include their views on gaps in
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Brahm H. Segal Editor
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Management of Infections in the Immunocompromised Host
Brahm H. Segal Editor
Management of Infections in the Immunocompromised Host
Editor Brahm H. Segal Departments of Medicine and Immunology Roswell Park Comprehensive Cancer Center Buffalo, NY, USA Department of Medicine University at Buffalo Jacobs School of Medicine and Biomedical Sciences Buffalo, NY, USA
ISBN 978-3-319-77672-9 ISBN 978-3-319-77674-3 (eBook) https://doi.org/10.1007/978-3-319-77674-3 Library of Congress Control Number: 2018943702 © Springer International Publishing AG, part of Springer Nature 2018 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Printed on acid-free paper This Springer imprint is published by the registered company Springer International Publishing AG part of Springer Nature. The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
To my wife, Stephanie, and to our children, Joshua and Emily.
Preface
“Now inflammation as understood in man and the higher animals is a phenomenon that almost always results from the intervention of some pathogenic microbe. So it is held that the afflux of mobile cells towards points of lesion shows the organism’s reaction against foreign bodies in general and against infectious microbes in particular. On this hypothesis, disease would be a fight between the morbid agent, the microbe from outside, and the mobile cells of the organism itself. Cure would come from the victory of the cells and immunity would be the sign of their acting sufficiently to prevent the microbial onslaught” (Ilya Mechnikov, Nobel lecture, 1908). Mechnikov’s conclusions were based on his seminal experiments involving the application of splinters to larvae of the starfish, Bipinnaria, that led to the discovery of phagocytosis as a critical factor in host defense. In the same lecture, Mechnikov noted that individ
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