Mastadenovirus
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. Human adenovirus 4. Fig. 1 Negative contrast electron micrograph of virus particle
Virion Morphology:
Icosahedral
Envelope:
No
Diameter (nm):
80
Length (nm):
–
Structural components:
Core, capsid
Buoyant density (g/mL):
1.34
Buoyant density method:
CsCl
Lipid composition:
No
Additional information:
Antenna-like 10–50 nm long fibers (polypeptide IV) protrude from the 12 vertices
C. Tidona, G. Darai (eds.), The Springer Index of Viruses, DOI 10.1007/978-0-387-95919-1, # Springer Science+Business Media, LLC 2011
34
Mastadenovirus
Genome Nucleic acid:
DNA
Strandedness:
Double-stranded
Polarity:
–
Configuration:
Linear
Segment organization: Segment no. 1 (kb): One Segment(s): G + C content (%):
30–37 30–37 (kb) total (calculated)
41–64
mRNA transcripts: Open reading frames:
30–46
Additional information: Genome has 93–371 bp inverted terminal repeats (ITR), four early regions and two structural regions with one major late promotor; primate AdVs have one or two VA RNA genes
Replication Entry mechanism:
Attachment, internalization, and penetration receptors: CAR, avb3, avb5
Site of transcription:
Nucleus
Transcriptase:
Cellular RNA polymerase II
Site of genome replication: Nucleus Replicase:
Virus-encoded DNA-dependent DNA polymerase
Replication intermediate:
Panhandle intermediate basepaired via ITRs
Site of virion assembly:
Nucleus
Egress mechanism:
Rupture of nuclear membrane; adenovirus death protein (ADP) in primate AdVs
Additional information:
High accumulation of virus progeny in nuclei
History Year of event Event
References
1889
Keratitis punctata superficials
Fuchs E (1889) Wein Klin Biochem Schr 2:837
1930
Epizootic fox encephalitis
Green RG et al (1930) Am J Hyg 12:109–129
1948
Description of acute hepatitis in dogs, the so called Rubarth S (1948) Acta Path Microbiol Scand 25:122 Rubarth disease
1953
First identification of adenoviruses
1954
Canine adenovirus type 1 isolated from a dog with Cabasso VJ (1954) Proc Soc Exp Biol Med 85:239–245 acute hepatitis
1955
Demonstration of human adenovirus 8 as the cause Jawetz E et al (1955) Science 122:1190–1191 of epidemic keratoconjunctivitis
Rowe WP et al (1953) Proc Soc Exp Biol Med 84:570–573
Mastadenovirus
Year of event Event
References
1959
Description of the icosahedral structure of the adenovirus capsid
Horne RW (1959) J Mol Biol 1:84–86
1959
First demonstration of a bovine adenovirus
Klein M et al (1959) Proc Soc Exp Biol Med 102:1–4
1960
First demonstration of a murine adenovirus
Hartley JW, Rowe WP (1960) Virology 11:645–647
1960
Establishment of hemagglutination inhibition as the method for typing of adenoviruses
Rosen L (1960) Am J Hyg 71:120–128
1962
Demonstration of the oncogenicity of the human adenovirus type 12 in newborn hamsters
Trentin JJ et al (1962) Science 137:835–847
1964
Description of adenovirus in pigs
Haig DA et al (1964) J Comp Pathol 74:81–84
1965
First description of antenna-like fiber protruding from each vertex of the adenovirus capsid
Valentine
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