Maternal physical activity and sedentary behaviour before and during in vitro fertilization treatment: a longitudinal st
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ASSISTED REPRODUCTION TECHNOLOGIES
Maternal physical activity and sedentary behaviour before and during in vitro fertilization treatment: a longitudinal study exploring the associations with controlled ovarian stimulation and pregnancy outcomes Deniss Sõritsa 1,2 & Evelin Mäestu 3 & Margit Nuut 4 & Jarek Mäestu 3 & Jairo H. Migueles 5 & Siret Läänelaid 6,7 & Aivar Ehrenberg 4 & Aire Sekavin 4 & Andrei Sõritsa 2 & Andres Salumets 1,8,9 & Francisco B. Ortega 5,10 & Signe Altmäe 8,11,12 Received: 21 January 2020 / Accepted: 16 June 2020 # Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Purpose To evaluate the association of objectively measured physical activity (PA) and sedentary behaviour before and during in vitro fertilization (IVF) with controlled ovarian stimulation (COS) and pregnancy outcomes. Methods This longitudinal study involved 107 infertile women undergoing IVF treatment. PA and sedentary behaviour were measured for 14 consecutive days using accelerometry as follows: (1) before IVF treatment, (2) during IVF at the implantation time, immediately after embryo transfer, and (3) after positive pregnancy test. Total screen time was assessed by questionnaires. COS results were measured as the number of oocytes and embryos obtained, and the study outcomes included positive hCG, clinical pregnancy, and live birth. Results Compared with baseline activity levels, women significantly reduced their PA and increased sedentary behaviour during IVF (p ≤ 0.001). Higher average PA, light PA, and ratio between breaks in every ≥ 30-min blocks of sedentary time showed positive associations, while sedentary time, number, and time accumulated in blocks of ≥ 30 min of sedentary time associated negatively with oocyte and embryo counts (all p < 0.05). Women with high total screen time during non-work days (≥ 7 h) obtained 4.7 oocytes (p = 0.005) and 2.8 embryos (p = 0.008) less in COS. PA and sedentary behaviour before and during IVF did not affect the positive hCG, clinical pregnancy, and live birth outcomes. Key message Higher levels of light physical activity and shorter sedentary behaviour and screen-watching times before entering infertility treatment associate with better ovarian stimulation outcomes under IVF treatment protocols. Electronic supplementary material The online version of this article (https://doi.org/10.1007/s10815-020-01864-w) contains supplementary material, which is available to authorized users. * Signe Altmäe [email protected] 1
Department of Obstetrics and Gynaecology, Institute of Clinical Medicine, University of Tartu, 51014 Tartu, Estonia
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Department of Family Medicine, Faculty of Medicine, University of Tartu, 50411 Tartu, Estonia
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Tartu Health Care College, 50411 Tartu, Estonia
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Competence Centre on Health Technologies, 50410 Tartu, Estonia
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Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, FI-00029 HUS Helsinki, Finland
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Elite Clinic, 50407 Tartu, Estonia
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Faculty of Medicine, Institute of Sport Sci
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