Mathematical Modeling of Epithelial Ion Transport

In this chapter, we provide a general introduction to mathematical modeling of epithelial ion transport. The basic mathematical concepts are introduced and the instantiation of these concepts into numerical simulation is demonstrated. Tools and technologi

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Kirk L. Hamilton Daniel C. Devor  Editors

Basic Epithelial Ion Transport Principles and Function Ion Channels and Transporters of Epithelia in Health and Disease - Vol. 1 Second Edition

Physiology in Health and Disease Published on behalf of the American Physiological Society by Springer

Physiology in Health and Disease This book series is published on behalf of the American Physiological Society (APS) by Springer. Access to APS books published with Springer is free to APS members. APS publishes three book series in partnership with Springer: Physiology in Health and Disease (formerly Clinical Physiology), Methods in Physiology, and Perspectives in Physiology (formerly People and Ideas), as well as general titles.

More information about this series at http://www.springer.com/series/11780

Kirk L. Hamilton • Daniel C. Devor Editors

Basic Epithelial Ion Transport Principles and Function Ion Channels and Transporters of Epithelia in Health and Disease - Vol. 1 Second Edition

Editors Kirk L. Hamilton Department of Physiology, School of Biomedical Sciences University of Otago Dunedin, Otago, New Zealand

Daniel C. Devor Department of Cell Biology University of Pittsburgh Pittsburgh, PA, USA

ISSN 2625-252X ISSN 2625-2538 (electronic) Physiology in Health and Disease ISBN 978-3-030-52779-2 ISBN 978-3-030-52780-8 (eBook) https://doi.org/10.1007/978-3-030-52780-8 © The American Physiological Society 2016, 2020 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, expressed or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Switzerland AG. The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland

We dedicate this second edition to our families . . . Judy, Nathan, and Emma for KLH, and Cathy, Caitlin, Emily, and Daniel for DCD.

Preface to Second Edition—Volume 1

Our ultimate goal for the first edition of Ion Channels and Transpo

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