Mathematical Modelling of Haemodialysis Cardiovascular Response, Bod
Beginning with an introduction to kidney function, renal replacement therapies, and an overview of clinical problems associated with haemodialysis, this book explores the principles of the short-term baroreflex regulation of the cardiovascular system and
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thematical Modelling of Haemodialysis Cardiovascular Response, Body Fluid Shifts, and Solute Kinetics
Mathematical Modelling of Haemodialysis
Leszek Pstras • Jacek Waniewski
Mathematical Modelling of Haemodialysis Cardiovascular Response, Body Fluid Shifts, and Solute Kinetics
Leszek Pstras Polish Academy of Sciences Nalecz Institute of Biocybernetics and Biomedical Engineering Warsaw, Poland
Jacek Waniewski Polish Academy Science Nalecz Institute of Biocybernetics and Biomedical Engineering Warsaw, Poland
ISBN 978-3-030-21409-8 ISBN 978-3-030-21410-4 https://doi.org/10.1007/978-3-030-21410-4
(eBook)
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Preface
Almost four million people around the world are diagnosed with end-stage renal disease (ESRD), i.e. a chronic kidney failure. Most of these patients (over 80%) receive regular dialysis treatment to substitute the most important, life-saving functions of a healthy kidney, i.e. to remove excess water, waste products of metabolism and foreign chemicals from the body, to maintain the physiological levels of electrolytes and to correct the metabolic acidosis. The most common dialysis treatment is haemodialysis (HD) – an extracorporeal technique – in which the patient’s blood is cleared from unwanted solutes and excess water in a dialyzer. While being a life-sustaining treatment for patients with ESRD, haemodialysis imposes a significant burden on the cardiovascular system. During a standard HD session, a few litres of fluid (water and solutes) are removed from the body over a relatively short period of time (typically 3–5 hours). The majority of dialysed patients can deal with the reduction in blood volu
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