Maximum standardized uptake value from quantitative bone single-photon emission computed tomography/computed tomography
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ORIGINAL ARTICLE
Maximum standardized uptake value from quantitative bone single‑photon emission computed tomography/computed tomography in differentiating metastatic and degenerative joint disease of the spine in prostate cancer patients Mohd Fazrin Mohd Rohani1,2,6 · Norazlina Mat Nawi1,2 · Syed Ejaz Shamim1,2 · Wan Fatihah Wan Sohaimi1,2 · Wan Mohd Nazlee Wan Zainon3 · Marianie Musarudin4 · Mohamad Aminudin Said5 · Hazlin Hashim6 Received: 17 July 2019 / Accepted: 8 October 2019 © The Japanese Society of Nuclear Medicine 2019
Abstract Objective Qualitative interpretation in bone scan is often complicated by the presence of degenerative joint disease (DJD), especially in the elderly patient. The aim of this study is to compare objectively 99mTc-MDP tracer uptake between DJD and osseous metastases of the spine using semi-quantitative assessment with SPECT SUV. Methods Bone scan with SPECT/CT using 99mTc-MDP was performed in 34 patients diagnosed with prostate carcinoma. SPECT/CT was performed based on our institutional standard guidelines. SUVmax based on body weight in 238 normal vertebrae visualized on SPECT/CT was quantified as baseline. A total of 211 lesions in the spine were identified on bone scan. Lesions were characterized into DJD or bone metastases based on its morphology on low-dose CT. Semi-quantitative evaluation using SUVmax was then performed on 89 DJD and 122 metastatic bone lesions. As most of the bone lesions were small in volume, the effect of partial volume effect (PVE) on S UVmax was also assessed. The corrected S UVmax values were obtained based on the recovery coefficient (RC) method. Results The mean SUVmax for normal vertebrae was 7.08 ± 1.97, 12.59 ± 9.01 for DJD and 36.64 ± 24.84 for bone metastases. The SUVmax of bone metastases was significantly greater than DJD (p value
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