Mechanisms and Mediators of Neuropathic Pain
Numerous improvements in our understanding of the mechanisms that underlie neuropathic pain states have come from the development of animal models, most of which involve partial peripheral nerve injury. The animal models have shown that nerve injury initi
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Mechanisms and Mediators of Neuropathic Pain
Annika B. Malmberg Sandra R. Chaplan Editors
Springer Basel AG
Editors Sandra R. Chaplan (MD) RW Johnson Pharmaceuticallnstitute 3210 Merryfield Row San Diego, CA 92121 USA
Annika B. Malmberg (PhD) NeurogesX, Inc. 969C Industrial Road San Carlos, CA 94070 USA
A CIP catalogue record for this book is available from the Library of Congress, Washington D.C., USA
Deutsche Bibliothek Cataloging-in-Publication Data Mechanisms and mediators of neuropathic pain / Annika B. Malmberg ; Sandra R. Chaplan, ed .. - Basel ; Boston; Berlin: Birkhâuser, 2002 (progress in inflammation research)
ISBN 978-3-0348-9448-7
ISBN 978-3-0348-8129-6 (eBook)
DOI 10.1007/978-3-0348-8129-6
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ISBN 978-3-0348-9448-7 This work is subject to copyright. AII rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, re-use of iIIustrations, recitation, broadcasting, reproduction on microfilms or in other ways, and storage in data banks. For any kind of use, permission of the copyright owner must be obtained.
© 2002 Springer Basel AG Origina11y published by Birkhâuser Verlag in 2002 Softcover reprint of the hardcover 1st edition 2002 Member of the BertelsmannSpringer Publishing Group Printed on acid-free paper produced from chlorine-free pulp. TCF ~ Cover design: Markus Etterich, Basel Cover iIIustration: Neuropeptide Y-immunoreactive neurons in the mouse spinal cord. Photo contributed by Nigel A. Calcutt.
ISBN 978-3-0348-9448-7 987654321
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Contents
List of contributors
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Preface
.
.
vii xi
Peripheral consequences of nerve injury Martin Michaelis Electrophysiological characteristics of injured peripheral nerves Joel A. Black, Theodore R. Cummins, Sulayman D. Dib-Ha;; and Stephen G. Waxman Sodium channels and the molecular basis for pain Valerie M.K. Verge, Tracy D. Wilson-Gerwing, Laurie A. Karchewski and Kelly A. Gratto Changes in DRG neur
