Medical Informatics Knowledge Management and Data Mining in Biomedic

Knowledge Management and Data Mining in Biomedicine covers the basic foundations of the area while extending the foundational material to include the recent leading-edge research in the field. The newer concepts, techniques, and practices of biomedical kn

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INTEGRATED SERIES IN INFORMATION SYSTEMS Series Editors Professor Ramesh Sharda Oklahoma State University

Prof. Dr. Stefan Vo13 Universitat Hamburg

Other published titles in the series: E-BUSINESS MANAGEMENT: Integration of Web Technologies with Business Models1 Michael J . Shaw VIRTUAL CORPORATE UNIVERSITIES: A Matrix of Knowledge and Learning for the New Digital DawdWalter R.J. Baets & Gert Van der Linden SCALABLE ENTERPRISE SYSTEMS: An Introduction to Recent Advances1 edited by Vittal Prabhu, Soundar Kumara, Manjunath Kamath LEGAL PROGRAMMING: Legal Compliance for RFID and Software Agent Ecosystems in Retail Processes and Beyond1 Brian Subirana and Malcolm Bain LOGICAL DATA MODELING: What It Is and How To Do It1 Alan Chmura and J. Mark Heumann DESIGNING AND EVALUATING E-MANAGEMENT DECISION TOOLS: The Integration of Decision and Negotiation Models into Internet-Multimedia Technologies1Giampiero E.G. Beroggi INFORMATION AND MANAGEMENT SYSTEMS FOR PRODUCT CUSTOMIZATIONI Blecker, Friedrich, Kaluza, Abdelkafi & Kreutler

MEDICAL INFORMATICS Knowledge Management and Data Mining in Biomedicine

edited by

Hsinchun Chen Sherrilynne S. Fuller Carol Friedman William Hersh

- Springer

Hsinchun Chen The University of Arizona, USA

Sherrilynne S. Fuller University of Washington, USA

Carol Friedman Columbia University, USA

William Hersh Oregon Health & Science Univ., USA

Library of Congress Cataloging-in-Publication Data A C.I.P. Catalogue record for this book is available from the Library of Congress.

ISBN-10: 0-387-24381-X (HB) ISBN- 13: 978-0387-24381-8 (HB)

ISBN- 10: 0-387-25739-X (e-book) ISBN- 13: 978-0387-25739-6 (e-book)

O 2005 by Springer Science+Business Media, Inc.

All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Springer Science + Business Media, Inc., 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now know or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks and similar terms, even if the are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. Printed in the United States of America. 9 8 7 6 5 4 3 2 1

SPIN 1 1055556

TABLE OF CONTENTS Editors' Biographies .......................................................................... xix Authors' Biographies ....................................................................... xxiii Preface ............................................................................................ xxxix

UNIT I: Foundational Topics in Medical Informatics Chapter 1: Knowledge Management. Data Mining. and Text Mining in Medical Informatics

..........................................................3

Introduction .....................