Mesna
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First report of photodistributed dermatosis: case report A 41-year-old man developed a photodistributed dermatosis while receiving mesna. The man was admitted with a pruritic rash, which was exacerbated by sun exposure. The eruption had developed 1 month after starting mesna [dosage and route not stated] for cyclophosphamide-induced haemorrhagic cystitis. Examination revealed a papular erythematous rash, which was photodistributed on his arms, trunk and face. Tests revealed pancytopenia and normochromic normocytic anaemia. Biopsy revealed a lichenoid tissue reaction with lymphocyte exocytosis, basal cell apoptosis and a heavy inflammatory cell infiltrate in the superficial dermis. The findings were consistent with a photoinduced drug eruption. Mesna was withdrawn, and the man received promethazine, clobetasol, clobetasone and emollients. Eight weeks later, the rash completely resolved. Lin CY, et al. Mesna-induced photodistributed dermatosis. Clinical and Experimental Dermatology 37: 358-360, No. 4, Jun 2012. Available from: URL: 803074962 http://dx.doi.org/10.1111/j.1365-2230.2011.04233.x - New Zealand
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Editorial comment: A search of AdisBase, Medline, Embase and the WHO ADR database did not reveal any previous case reports of photodermatosis associated with mesna.
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Reactions 11 Aug 2012 No. 1414
