Metabolic syndrome in women with and without interstitial cystitis/bladder pain syndrome

  • PDF / 521,502 Bytes
  • 8 Pages / 595.276 x 790.866 pts Page_size
  • 47 Downloads / 205 Views

DOWNLOAD

REPORT


ORIGINAL ARTICLE

Metabolic syndrome in women with and without interstitial cystitis/bladder pain syndrome Liao Peng 1 & Xing-peng Di 1 & Shi-xin He 2 & Xiao Zeng 1 & Hong Shen 1 & Hui-li Zhu 3 & De-yi Luo 1 Received: 16 July 2020 / Accepted: 10 November 2020 # The International Urogynecological Association 2020

Abstract Introduction and hypothesis The aim of this study was to compare the frequency of metabolic syndrome (MetS) in patients with and without interstitial cystitis/bladder pain syndrome (IC/BPS). Methods This case-control study evaluated the indicators of MetS in 287 females with IC/BPS and in 287 females without IC/ BPS in West China Hospital between January 2010 and January 2020. Then, the number of voids per day, frequency of night urination, O’Leary-Sant Interstitial Cystitis Symptom/Problem Index, and visual analog scale were examined in the two groups. Results Based on both the National Cholesterol Education Program Adult Treatment Panel III recommendations and the International Diabetes Federation criteria, the distribution of MetS was statistically higher in patients with IC/BPS than in the control group, with 34.8% vs 17.8% (P < 0.0001) and 34.2% vs 20.9% (P = 0.0005), respectively. Regarding symptom scores, the IC/BPS group demonstrated significantly higher scores than the control group in all aspects (P < 0.0001). More patients with anxiety (P < 0.0001), insomnia (P < 0.0001), hypertension (P = 0.0001), and diabetes mellitus (P = 0.017) were observed in the IC/BPS group. Moreover, the findings indicated that patients with IC/BPS had a higher BMI (P = 0.0001) and larger waist circumference (P = 0.0001). Blood tests presented a significantly higher level of fasting glycemia, serum cystatin-C, and triglycerides in patients with IC/BPS. Furthermore, higher ORs for the occurrence of MetS among cases were observed, although this was not statistically significant. Conclusions MetS frequency was relatively high in patients with IC/BPS. Further research is needed to understand the common pathophysiologic mechanism of IC/BPS and MetS. Keywords Metabolic syndrome . Obesity . Body mass index . Interstitial cystitis/bladder pain syndrome

Introduction

Liao Peng, Xing-peng Di and Shi-xin He contributed equally to this work. * Hui-li Zhu [email protected] * De-yi Luo [email protected] 1

Department of Urology, Institute of Urology, West China Hospital, Sichuan University, No. 37 Guo Xue Xiang, Chengdu, Sichuan 610041, People’s Republic of China

2

Department of Dermatology, the First Affiliated Hospital of Chengdu Medical College, Xindu, Sichuan, People’s Republic of China

3

Department of Obstetrics and Gynecology, West China Second University Hospital of Sichuan University, No. 20, Section 3, Renmin Nan Lu, Chengdu 610041, Sichuan, China

Metabolic syndrome (MetS) is characterized by a cluster of metabolic risk factors, including obesity, dyslipidemia, elevated blood pressure, and elevated fasting glucose [1]. These factors are reported to be linked with cardiovascular disease and diabetes mellitu